Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy
The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminesce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/10/2015 |
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| author | Douglas L. Fritzen Luidgi Giordano Lucas C. V. Rodrigues Jorge H. S. K. Monteiro |
| author_facet | Douglas L. Fritzen Luidgi Giordano Lucas C. V. Rodrigues Jorge H. S. K. Monteiro |
| author_sort | Douglas L. Fritzen |
| collection | DOAJ |
| description | The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed. |
| first_indexed | 2024-03-10T15:40:06Z |
| format | Article |
| id | doaj.art-10bc537bb8ef4b809aee7a9a9f94fb0d |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T15:40:06Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-10bc537bb8ef4b809aee7a9a9f94fb0d2023-11-20T16:50:35ZengMDPI AGNanomaterials2079-49912020-10-011010201510.3390/nano10102015Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic TherapyDouglas L. Fritzen0Luidgi Giordano1Lucas C. V. Rodrigues2Jorge H. S. K. Monteiro3Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo-SP 05508-000, BrazilDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo-SP 05508-000, BrazilDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo-SP 05508-000, BrazilDepartment of Chemistry, Humboldt State University, Arcata, CA 95521, USAThe use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation in the UV-Vis. This review aims to provide a background in luminescence imaging of biological systems, persistent luminescence, and synthetic methods for obtaining persistent luminescent materials, and discuss selected examples of recent literature on the applications of persistent luminescent materials in luminescence imaging of biological systems and photodynamic therapy. Finally, the challenges and future directions, pointing to the development of compounds capable of executing multiple functions and light in regions where tissues and cells have low absorption, will be discussed.https://www.mdpi.com/2079-4991/10/10/2015persistent luminescenceluminescence imagingtheranosticsphotodynamic therapy |
| spellingShingle | Douglas L. Fritzen Luidgi Giordano Lucas C. V. Rodrigues Jorge H. S. K. Monteiro Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy Nanomaterials persistent luminescence luminescence imaging theranostics photodynamic therapy |
| title | Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy |
| title_full | Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy |
| title_fullStr | Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy |
| title_full_unstemmed | Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy |
| title_short | Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy |
| title_sort | opportunities for persistent luminescent nanoparticles in luminescence imaging of biological systems and photodynamic therapy |
| topic | persistent luminescence luminescence imaging theranostics photodynamic therapy |
| url | https://www.mdpi.com/2079-4991/10/10/2015 |
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