Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction
In this study, the images of specific prompt gamma (PG)-rays of 719 keV emitted from proton–boron reactions were analyzed using single-photon emission computed tomography (SPECT). Quantitative evaluation of the images verified the detection of anatomical changes in tumors, one of the important facto...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Nuclear Engineering and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1738573322001255 |
| _version_ | 1828149872208904192 |
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| author | Min-Geon Choi Martin Law Shin-Kien Djeng Moo-Sub Kim Han-Back Shin Bo-Young Choe Do-Kun Yoon Tae Suk Suh |
| author_facet | Min-Geon Choi Martin Law Shin-Kien Djeng Moo-Sub Kim Han-Back Shin Bo-Young Choe Do-Kun Yoon Tae Suk Suh |
| author_sort | Min-Geon Choi |
| collection | DOAJ |
| description | In this study, the images of specific prompt gamma (PG)-rays of 719 keV emitted from proton–boron reactions were analyzed using single-photon emission computed tomography (SPECT). Quantitative evaluation of the images verified the detection of anatomical changes in tumors, one of the important factors in daily adaptive proton therapy (DAPT) and verified the possibility of application of the PG-ray images to DAPT. Six scenarios were considered based on various sizes and locations compared to the reference virtual tumor to observe the anatomical alterations in the virtual tumor. Subsequently, PG-rays SPECT images were acquired using the modified ordered subset expectation-maximization algorithm, and these were evaluated using quantitative analysis methods. The results confirmed that the pixel range and location of the highest value of the normalized pixel in the PG-rays SPECT image profile changed according to the size and location of the virtual tumor. Moreover, the alterations in the virtual tumor size and location in the PG-rays SPECT images were similar to the true size and location alterations set in the phantom. Based on the above results, the tumor anatomical alterations in DAPT could be adequately detected and verified through SPECT imaging using the 719 keV PG-rays acquired during treatment. |
| first_indexed | 2024-04-11T21:36:19Z |
| format | Article |
| id | doaj.art-10c570d6db5144b3be4720187ecbaafb |
| institution | Directory Open Access Journal |
| issn | 1738-5733 |
| language | English |
| last_indexed | 2024-04-11T21:36:19Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nuclear Engineering and Technology |
| spelling | doaj.art-10c570d6db5144b3be4720187ecbaafb2022-12-22T04:01:44ZengElsevierNuclear Engineering and Technology1738-57332022-08-0154830063016Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reactionMin-Geon Choi0Martin Law1Shin-Kien Djeng2Moo-Sub Kim3Han-Back Shin4Bo-Young Choe5Do-Kun Yoon6Tae Suk Suh7Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South KoreaProton Therapy Pte Ltd., 1 Biopolis Drive, 138622, SingaporeProton Therapy Pte Ltd., 1 Biopolis Drive, 138622, SingaporeDepartment of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South KoreaDepartment of Radiation Oncology, Yonsei Cancer Center, Yonsei University, College of Medicine, Seoul, 03722, South KoreaDepartment of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South KoreaDepartment of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea; Corresponding author.Department of Biomedicine & Health Science and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul, 505, South Korea; Corresponding author.In this study, the images of specific prompt gamma (PG)-rays of 719 keV emitted from proton–boron reactions were analyzed using single-photon emission computed tomography (SPECT). Quantitative evaluation of the images verified the detection of anatomical changes in tumors, one of the important factors in daily adaptive proton therapy (DAPT) and verified the possibility of application of the PG-ray images to DAPT. Six scenarios were considered based on various sizes and locations compared to the reference virtual tumor to observe the anatomical alterations in the virtual tumor. Subsequently, PG-rays SPECT images were acquired using the modified ordered subset expectation-maximization algorithm, and these were evaluated using quantitative analysis methods. The results confirmed that the pixel range and location of the highest value of the normalized pixel in the PG-rays SPECT image profile changed according to the size and location of the virtual tumor. Moreover, the alterations in the virtual tumor size and location in the PG-rays SPECT images were similar to the true size and location alterations set in the phantom. Based on the above results, the tumor anatomical alterations in DAPT could be adequately detected and verified through SPECT imaging using the 719 keV PG-rays acquired during treatment.http://www.sciencedirect.com/science/article/pii/S1738573322001255Proton–boron fusion reactionPrompt gamma raySPECTAdaptive proton therapy |
| spellingShingle | Min-Geon Choi Martin Law Shin-Kien Djeng Moo-Sub Kim Han-Back Shin Bo-Young Choe Do-Kun Yoon Tae Suk Suh Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction Nuclear Engineering and Technology Proton–boron fusion reaction Prompt gamma ray SPECT Adaptive proton therapy |
| title | Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction |
| title_full | Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction |
| title_fullStr | Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction |
| title_full_unstemmed | Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction |
| title_short | Daily adaptive proton therapy: Feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton–boron fusion reaction |
| title_sort | daily adaptive proton therapy feasibility study of detection of tumor variations based on tomographic imaging of prompt gamma emission from proton boron fusion reaction |
| topic | Proton–boron fusion reaction Prompt gamma ray SPECT Adaptive proton therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1738573322001255 |
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