X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis”
X-chromosome inactivation (XCI) and random monoallelic expression of autosomal genes (RMAE) are two paradigms of gene expression regulation where, at the single cell level, genes can be expressed from either the maternal or paternal alleles. X-chromosome inactivation takes place in female marsupial...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.740937/full |
| _version_ | 1818602999290789888 |
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| author | Vasco M. Barreto Nadiya Kubasova Clara F. Alves-Pereira Anne-Valerie Gendrel |
| author_facet | Vasco M. Barreto Nadiya Kubasova Clara F. Alves-Pereira Anne-Valerie Gendrel |
| author_sort | Vasco M. Barreto |
| collection | DOAJ |
| description | X-chromosome inactivation (XCI) and random monoallelic expression of autosomal genes (RMAE) are two paradigms of gene expression regulation where, at the single cell level, genes can be expressed from either the maternal or paternal alleles. X-chromosome inactivation takes place in female marsupial and placental mammals, while RMAE has been described in mammals and also other species. Although the outcome of both processes results in random monoallelic expression and mosaicism at the cellular level, there are many important differences. We provide here a brief sketch of the history behind the discovery of XCI and RMAE. Moreover, we review some of the distinctive features of these two phenomena, with respect to when in development they are established, their roles in dosage compensation and cellular phenotypic diversity, and the molecular mechanisms underlying their initiation and stability. |
| first_indexed | 2024-12-16T13:16:12Z |
| format | Article |
| id | doaj.art-10c9d1dec9b14871a592c46ba22d4f25 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T13:16:12Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-10c9d1dec9b14871a592c46ba22d4f252022-12-21T22:30:29ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.740937740937X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis”Vasco M. Barreto0Nadiya Kubasova1Clara F. Alves-Pereira2Anne-Valerie Gendrel3Chronic Diseases Research Centre, CEDOC, Nova Medical School, Lisbon, PortugalChronic Diseases Research Centre, CEDOC, Nova Medical School, Lisbon, PortugalDepartment of Genetics, Smurfit Institute of Genetics, Trinity College Dublin, University of Dublin, Dublin, IrelandInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisbon, PortugalX-chromosome inactivation (XCI) and random monoallelic expression of autosomal genes (RMAE) are two paradigms of gene expression regulation where, at the single cell level, genes can be expressed from either the maternal or paternal alleles. X-chromosome inactivation takes place in female marsupial and placental mammals, while RMAE has been described in mammals and also other species. Although the outcome of both processes results in random monoallelic expression and mosaicism at the cellular level, there are many important differences. We provide here a brief sketch of the history behind the discovery of XCI and RMAE. Moreover, we review some of the distinctive features of these two phenomena, with respect to when in development they are established, their roles in dosage compensation and cellular phenotypic diversity, and the molecular mechanisms underlying their initiation and stability.https://www.frontiersin.org/articles/10.3389/fcell.2021.740937/fullX-chromosome inactivationrandom monoallelic expressionepigenetic silencingLINE-1 elementscellular diversitystochasticity |
| spellingShingle | Vasco M. Barreto Nadiya Kubasova Clara F. Alves-Pereira Anne-Valerie Gendrel X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis” Frontiers in Cell and Developmental Biology X-chromosome inactivation random monoallelic expression epigenetic silencing LINE-1 elements cellular diversity stochasticity |
| title | X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis” |
| title_full | X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis” |
| title_fullStr | X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis” |
| title_full_unstemmed | X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis” |
| title_short | X-Chromosome Inactivation and Autosomal Random Monoallelic Expression as “Faux Amis” |
| title_sort | x chromosome inactivation and autosomal random monoallelic expression as faux amis |
| topic | X-chromosome inactivation random monoallelic expression epigenetic silencing LINE-1 elements cellular diversity stochasticity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.740937/full |
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