Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure
Yunjian Sheng,1,* Yu Zeng,1,* Wenling Luo,1 Xuemei Zhang,1 Hang Wang,2 Jiahuan Jiao3 1Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Gastroenterology, Dazhou Hospital of Integrated Traditi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-10-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/predictive-value-of-the-prothrombin-time-international-normalized-rati-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797658950477283328 |
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| author | Sheng Y Zeng Y Luo W Zhang X Wang H Jiao J |
| author_facet | Sheng Y Zeng Y Luo W Zhang X Wang H Jiao J |
| author_sort | Sheng Y |
| collection | DOAJ |
| description | Yunjian Sheng,1,* Yu Zeng,1,* Wenling Luo,1 Xuemei Zhang,1 Hang Wang,2 Jiahuan Jiao3 1Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Gastroenterology, Dazhou Hospital of Integrated Traditional and Western Medicine, Dazhou, Sichuan, People’s Republic of China; 3Department of Infectious Diseases, the People’s Hospital of Leshan, Leshan, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunjian Sheng, Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan Province, People’s Republic of China, Email sheng200410@163.comBackground: Acute-on-chronic liver failure is a common clinical syndrome with high short-term mortality, and early assessment of its mortality risk is crucial, but the search for valid and accurate prognostic biomarkers is a challenging endeavor. The purpose of this study was to investigate the predictive value of the prothrombin time-international normalized ratio to albumin ratio (PTAR) for mortality in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Patients and methods: A total of 354 patients with HBV-ACLF were included in the retrospective study. Patients were divided into survival and non-survival groups based on 90-day follow-up. Cox regression analysis was used to explore the relationship between PTAR and 90-day mortality in patients with HBV-ACLF. The area under the receiver operating characteristic curve was used to evaluate the effectiveness of PTAR in predicting mortality.Results: PTAR was significantly higher in non-survivors than in survivors. The results of multivariate analysis showed that PTAR was a valid independent predictor of mortality in patients with HBV-ACLF. Its predictive ability for mortality was similar to that of the Child-Turcotte-Pugh score, the end-stage liver disease model (MELD) score, and the MELD-sodium score.Conclusion: PTAR may be a simple and effective tool for predicting the prognosis of patients with HBV-ACLF.Keywords: acute-on-chronic liver failure, hepatitis B virus, prothrombin time-international normalized ratio to albumin ratio, prognosis |
| first_indexed | 2024-03-11T18:07:54Z |
| format | Article |
| id | doaj.art-10cac8ef2560407eb4cf9aac0c16669c |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-03-11T18:07:54Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-10cac8ef2560407eb4cf9aac0c16669c2023-10-17T02:44:24ZengDove Medical PressInternational Journal of General Medicine1178-70742023-10-01Volume 164565457287208Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver FailureSheng YZeng YLuo WZhang XWang HJiao JYunjian Sheng,1,* Yu Zeng,1,* Wenling Luo,1 Xuemei Zhang,1 Hang Wang,2 Jiahuan Jiao3 1Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Department of Gastroenterology, Dazhou Hospital of Integrated Traditional and Western Medicine, Dazhou, Sichuan, People’s Republic of China; 3Department of Infectious Diseases, the People’s Hospital of Leshan, Leshan, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunjian Sheng, Department of Infectious Diseases, the Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan Province, People’s Republic of China, Email sheng200410@163.comBackground: Acute-on-chronic liver failure is a common clinical syndrome with high short-term mortality, and early assessment of its mortality risk is crucial, but the search for valid and accurate prognostic biomarkers is a challenging endeavor. The purpose of this study was to investigate the predictive value of the prothrombin time-international normalized ratio to albumin ratio (PTAR) for mortality in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Patients and methods: A total of 354 patients with HBV-ACLF were included in the retrospective study. Patients were divided into survival and non-survival groups based on 90-day follow-up. Cox regression analysis was used to explore the relationship between PTAR and 90-day mortality in patients with HBV-ACLF. The area under the receiver operating characteristic curve was used to evaluate the effectiveness of PTAR in predicting mortality.Results: PTAR was significantly higher in non-survivors than in survivors. The results of multivariate analysis showed that PTAR was a valid independent predictor of mortality in patients with HBV-ACLF. Its predictive ability for mortality was similar to that of the Child-Turcotte-Pugh score, the end-stage liver disease model (MELD) score, and the MELD-sodium score.Conclusion: PTAR may be a simple and effective tool for predicting the prognosis of patients with HBV-ACLF.Keywords: acute-on-chronic liver failure, hepatitis B virus, prothrombin time-international normalized ratio to albumin ratio, prognosishttps://www.dovepress.com/predictive-value-of-the-prothrombin-time-international-normalized-rati-peer-reviewed-fulltext-article-IJGMacute-on-chronic liver failurehepatitis b virusprothrombin time-international normalized ratio to albumin ratioprognosis |
| spellingShingle | Sheng Y Zeng Y Luo W Zhang X Wang H Jiao J Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure International Journal of General Medicine acute-on-chronic liver failure hepatitis b virus prothrombin time-international normalized ratio to albumin ratio prognosis |
| title | Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure |
| title_full | Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure |
| title_fullStr | Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure |
| title_full_unstemmed | Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure |
| title_short | Predictive Value of the Prothrombin Time-International Normalized Ratio to Albumin Ratio in the Prognosis of Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure |
| title_sort | predictive value of the prothrombin time international normalized ratio to albumin ratio in the prognosis of patients with hepatitis b virus related acute on chronic liver failure |
| topic | acute-on-chronic liver failure hepatitis b virus prothrombin time-international normalized ratio to albumin ratio prognosis |
| url | https://www.dovepress.com/predictive-value-of-the-prothrombin-time-international-normalized-rati-peer-reviewed-fulltext-article-IJGM |
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