The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms

The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms

Intrinsic apoptosis, the response to intracellular cell death stimuli, is regulated by the interplay of the B-cell lymphoma 2 (Bcl-2) family and their membrane interactions. Bcl-2 proteins mediate a number of processes including development, homeostasis, autophagy, and innate and adaptive immune res...

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Bibliographic Details
Main Authors: Suresh Banjara, Chathura D. Suraweera, Mark G. Hinds, Marc Kvansakul
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Biomolecules
Subjects:
apoptosis
bcl-2
evolution
mechanism
structure analysis
Online Access:https://www.mdpi.com/2218-273X/10/1/128

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