Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study
Abstract Post-traumatic stress disorder (PTSD) is associated with the development of dementia; however, the association of dementia risk with overall stress-related disorders is less known. This study investigated the association between stress-related disorders and the risk of dementia in a Korean...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43884-3 |
| _version_ | 1797576813672660992 |
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| author | Hyunkyu Kim Yu Shin Park Seung Hoon Kim Kyungduk Hurh Jinhyun Kim Eun-Cheol Park Sung-In Jang |
| author_facet | Hyunkyu Kim Yu Shin Park Seung Hoon Kim Kyungduk Hurh Jinhyun Kim Eun-Cheol Park Sung-In Jang |
| author_sort | Hyunkyu Kim |
| collection | DOAJ |
| description | Abstract Post-traumatic stress disorder (PTSD) is associated with the development of dementia; however, the association of dementia risk with overall stress-related disorders is less known. This study investigated the association between stress-related disorders and the risk of dementia in a Korean nationwide sample cohort. The data analyzed in this study were acquired from the Korean National Health Insurance Service National Sample Cohort between 2002 and 2013. Using a 1:3 propensity score matching, 8906 patients with stress-related disorders and 26,718 control participants were included in the analysis. Patients with stress-related disorders had a higher risk of developing dementia after adjusting for covariates (hazard ratio [HR] = 1.15; 95% confidence interval [CI] 1.01–1.30) than control participants. Patients with PTSD showed the highest risk of increase (HR = 1.78) than those with other types of stress-related disorders. Patients with stress-related disorders showed the highest and significantly increased risk for Alzheimer’s dementia (HR = 1.22, 95% CI 1.04–1.56). These results indicated an association between a history of stress-related disorders and the risk of dementia in the South Korean population. Further research investigating the causal mechanisms is needed. |
| first_indexed | 2024-03-10T22:00:04Z |
| format | Article |
| id | doaj.art-10ce6c1b32ff48d7a2e1d22aa70055bf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T22:00:04Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-10ce6c1b32ff48d7a2e1d22aa70055bf2023-11-19T12:59:38ZengNature PortfolioScientific Reports2045-23222023-10-011311910.1038/s41598-023-43884-3Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort studyHyunkyu Kim0Yu Shin Park1Seung Hoon Kim2Kyungduk Hurh3Jinhyun Kim4Eun-Cheol Park5Sung-In Jang6Department of Preventive Medicine, Institute of Health Services Research, Yonsei University College of MedicineInstitute of Health Services Research, Yonsei UniversityInstitute of Health Services Research, Yonsei UniversityDepartment of Preventive Medicine, Institute of Health Services Research, Yonsei University College of MedicineDepartment of Preventive Medicine, Institute of Health Services Research, Yonsei University College of MedicineDepartment of Preventive Medicine, Institute of Health Services Research, Yonsei University College of MedicineDepartment of Preventive Medicine, Institute of Health Services Research, Yonsei University College of MedicineAbstract Post-traumatic stress disorder (PTSD) is associated with the development of dementia; however, the association of dementia risk with overall stress-related disorders is less known. This study investigated the association between stress-related disorders and the risk of dementia in a Korean nationwide sample cohort. The data analyzed in this study were acquired from the Korean National Health Insurance Service National Sample Cohort between 2002 and 2013. Using a 1:3 propensity score matching, 8906 patients with stress-related disorders and 26,718 control participants were included in the analysis. Patients with stress-related disorders had a higher risk of developing dementia after adjusting for covariates (hazard ratio [HR] = 1.15; 95% confidence interval [CI] 1.01–1.30) than control participants. Patients with PTSD showed the highest risk of increase (HR = 1.78) than those with other types of stress-related disorders. Patients with stress-related disorders showed the highest and significantly increased risk for Alzheimer’s dementia (HR = 1.22, 95% CI 1.04–1.56). These results indicated an association between a history of stress-related disorders and the risk of dementia in the South Korean population. Further research investigating the causal mechanisms is needed.https://doi.org/10.1038/s41598-023-43884-3 |
| spellingShingle | Hyunkyu Kim Yu Shin Park Seung Hoon Kim Kyungduk Hurh Jinhyun Kim Eun-Cheol Park Sung-In Jang Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study Scientific Reports |
| title | Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study |
| title_full | Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study |
| title_fullStr | Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study |
| title_full_unstemmed | Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study |
| title_short | Association between stress-related disorders and the risk of dementia using the Korean National Sample Cohort: a matched cohort study |
| title_sort | association between stress related disorders and the risk of dementia using the korean national sample cohort a matched cohort study |
| url | https://doi.org/10.1038/s41598-023-43884-3 |
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