Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis
Background: Enteropathy-Associated T-Cell Lymphoma (EATL) is a rare lymphoma of T-cell origin associated with celiac disease. There is limited evidence in the literature about the incidence and causes of death in patients with EATL. Methods: We performed a retrospective study through analyzing the S...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294223000679 |
| _version_ | 1797732838682918912 |
|---|---|
| author | Ahmed K. Awad Rehmat Ullah Awan Ayman K. Awad Ambreen Nabeel Sophia Dar Ayokunle T. Abegunde |
| author_facet | Ahmed K. Awad Rehmat Ullah Awan Ayman K. Awad Ambreen Nabeel Sophia Dar Ayokunle T. Abegunde |
| author_sort | Ahmed K. Awad |
| collection | DOAJ |
| description | Background: Enteropathy-Associated T-Cell Lymphoma (EATL) is a rare lymphoma of T-cell origin associated with celiac disease. There is limited evidence in the literature about the incidence and causes of death in patients with EATL. Methods: We performed a retrospective study through analyzing the Surveillance, Epidemiology, and End Results (SEER) data base to determine the incidence, trends and causes of death of patients with EATL in the U.S from 2000 to 2018. Baseline characteristics with treatment options (surgery, radiotherapy, and chemotherapy), status of patients either alive, dead due to cancer itself or other non-cancerous causes with listing of those non-cancerous causes was retrieved. Sub-group analysis based on sex was also done. Multiple latency periods (<2 year, 2–5, 6–10, 11–15, and more than 15 years) were analyzed following EATL diagnosis. Results: There were 259 EATL patients, majority were aged 70–74 years old (n = 36, 13.9%), predominantly males 155 (59.8%), most common in whites, (76.4%, n = 198), EATL was the only primary tumor in 177 (68.3%) cases, most common site was small bowel at different sites 84 (32.4%) followed by jejunum specifically 57 (22%), majority went for surgical resection (69.9%, n = 181) followed by chemotherapy (47.5%, n = 123), 217 (83.7%) died during follow-up in this study, Conclusion: EATL is a rare entity, mostly seen in males, between 70 and 74 years, and mostly originated in the small bowel. With over 80% death in five-year follow up period, EATL patients showed better survival if they underwent chemotherapy. More studies are needed for further understanding of this rare entity. |
| first_indexed | 2024-03-12T12:20:19Z |
| format | Article |
| id | doaj.art-10ce8cafb7224d70acc8cb6c376ea93d |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-03-12T12:20:19Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-10ce8cafb7224d70acc8cb6c376ea93d2023-08-30T05:54:28ZengElsevierCancer Treatment and Research Communications2468-29422023-01-0136100745Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysisAhmed K. Awad0Rehmat Ullah Awan1Ayman K. Awad2Ambreen Nabeel3Sophia Dar4Ayokunle T. Abegunde5Faculty of Medicine, Ain-Shams University, Cairo, Egypt; Corresponding author at: Faculty of Medicine, Ain-Shams University, Cairo, Egypt.Ochsner Rush Health, Dept Internal Medicine, Meridian, MS, USAFaculty of Medicine, El-Galala University, Suez, EgyptOchsner Rush Health, Dept Internal Medicine, Meridian, MS, USANorthshore University-Long Island Jewish Medical Center, Dept Internal Medicine, Manhasset, NY, USALoyola University Medical Center Chicago, Department of Gastroenterology, Chicago, IL, USABackground: Enteropathy-Associated T-Cell Lymphoma (EATL) is a rare lymphoma of T-cell origin associated with celiac disease. There is limited evidence in the literature about the incidence and causes of death in patients with EATL. Methods: We performed a retrospective study through analyzing the Surveillance, Epidemiology, and End Results (SEER) data base to determine the incidence, trends and causes of death of patients with EATL in the U.S from 2000 to 2018. Baseline characteristics with treatment options (surgery, radiotherapy, and chemotherapy), status of patients either alive, dead due to cancer itself or other non-cancerous causes with listing of those non-cancerous causes was retrieved. Sub-group analysis based on sex was also done. Multiple latency periods (<2 year, 2–5, 6–10, 11–15, and more than 15 years) were analyzed following EATL diagnosis. Results: There were 259 EATL patients, majority were aged 70–74 years old (n = 36, 13.9%), predominantly males 155 (59.8%), most common in whites, (76.4%, n = 198), EATL was the only primary tumor in 177 (68.3%) cases, most common site was small bowel at different sites 84 (32.4%) followed by jejunum specifically 57 (22%), majority went for surgical resection (69.9%, n = 181) followed by chemotherapy (47.5%, n = 123), 217 (83.7%) died during follow-up in this study, Conclusion: EATL is a rare entity, mostly seen in males, between 70 and 74 years, and mostly originated in the small bowel. With over 80% death in five-year follow up period, EATL patients showed better survival if they underwent chemotherapy. More studies are needed for further understanding of this rare entity.http://www.sciencedirect.com/science/article/pii/S2468294223000679Enteropathy-associated T-cell lymphomaNon-Hodgkin lymphomaSEER database |
| spellingShingle | Ahmed K. Awad Rehmat Ullah Awan Ayman K. Awad Ambreen Nabeel Sophia Dar Ayokunle T. Abegunde Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis Cancer Treatment and Research Communications Enteropathy-associated T-cell lymphoma Non-Hodgkin lymphoma SEER database |
| title | Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis |
| title_full | Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis |
| title_fullStr | Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis |
| title_full_unstemmed | Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis |
| title_short | Patients with enteropathy-associated T-cell lymphoma in the United States from 2000 to 2018: SEER data-base analysis |
| title_sort | patients with enteropathy associated t cell lymphoma in the united states from 2000 to 2018 seer data base analysis |
| topic | Enteropathy-associated T-cell lymphoma Non-Hodgkin lymphoma SEER database |
| url | http://www.sciencedirect.com/science/article/pii/S2468294223000679 |
| work_keys_str_mv | AT ahmedkawad patientswithenteropathyassociatedtcelllymphomaintheunitedstatesfrom2000to2018seerdatabaseanalysis AT rehmatullahawan patientswithenteropathyassociatedtcelllymphomaintheunitedstatesfrom2000to2018seerdatabaseanalysis AT aymankawad patientswithenteropathyassociatedtcelllymphomaintheunitedstatesfrom2000to2018seerdatabaseanalysis AT ambreennabeel patientswithenteropathyassociatedtcelllymphomaintheunitedstatesfrom2000to2018seerdatabaseanalysis AT sophiadar patientswithenteropathyassociatedtcelllymphomaintheunitedstatesfrom2000to2018seerdatabaseanalysis AT ayokunletabegunde patientswithenteropathyassociatedtcelllymphomaintheunitedstatesfrom2000to2018seerdatabaseanalysis |