Uric Acid and Coronary Artery Disease, Two Sides of a Single Coin: A Determinant of Antioxidant System or a Factor in Metabolic Syndrome
Introduction: Uric acid has antioxidant activity and it is expected to protect against coronary artery disease (CAD). Contradictory, it is a component of metabolic syndrome and so a risk factor for CAD. The associations of plasma total antioxidant capacity (TAOC) and uric acid (UA) as well as ot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7281/16335_CE(Ra1)_F(GH)_PF1(BMAK)_PFA(AK)_PF2(AGAK).pdf |
| Summary: | Introduction: Uric acid has antioxidant activity and it is expected
to protect against coronary artery disease (CAD). Contradictory,
it is a component of metabolic syndrome and so a risk factor
for CAD. The associations of plasma total antioxidant capacity
(TAOC) and uric acid (UA) as well as other risk factors were
investigated relative to the occurrence and severity of CAD.
Materials and Methods: The study population consisted of 148
males and 152 females aged 35-76 years who were classified
as CAD cases and controls according to the results of coronary
angiography. The severity of CAD was scored on the basis of
the number and the extent of lesions at coronary arteries. The
concentrations of UA and TAOC were measured by using of
FRAP and enzymatic uricase methods.
Results: The prevalence of hypertension, cigarette smoking
and diabetes mellitus was more frequent in CAD cases than
controls. Patients with CAD when compared with the controls
had increased levels of glucose, triglycerides, creatinine, UA,
TAOC and decreased levels of HDL- cholesterol. Serum UA
was high positive correlate of serum total and LDL-cholesterol,
triglyceride, creatinine, BUN, bilirubin, TAOC and negative
correlate of glucose and HDL-C. TAOC and its major determinant
UA but not bilirubin and albumin are significantly associated
with the prevalence and severity of CAD. In multivariate analysis
and in the absence of hypertension, UA but not TAOC would
remain and be associated with CAD by the OR of 1.57 (1.07-
2.29), p=0.02. If the results adjusted for all major risk factors
including hypertension, neither TAOC nor UA would remain in
the regression equation.
Conclusion: The results suggest that TAOC and UA but not
bilirubin and albumin are associated with CAD significantly.
But, the correlation is not independent and is attributed to the
metabolic syndrome. The measurement of UA and TAOC will
not improve the prognostic power beyond the classical risk
factors. |
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| ISSN: | 2249-782X 0973-709X |