Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745
Daldiniaeschsone A (<b>1</b>), a rare tricyclic polyketide having a chromone unit fused to a <i>δ</i>-lactone and its symmetrical 6,6′-biphenyl dimer, daldiniaeschsone B (<b>2</b>), together with three known compounds (<b>3</b>−<b>5</b>), w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/5/358 |
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| author | Natnicha Wutthiwong Virayu Suthiphasilp Aknarin Pintatum Nakarin Suwannarach Jaturong Kumla Saisamorn Lumyong Tharakorn Maneerat Rawiwan Charoensup Sarot Cheenpracha Thunwadee Limtharakul Stephen G. Pyne Surat Laphookhieo |
| author_facet | Natnicha Wutthiwong Virayu Suthiphasilp Aknarin Pintatum Nakarin Suwannarach Jaturong Kumla Saisamorn Lumyong Tharakorn Maneerat Rawiwan Charoensup Sarot Cheenpracha Thunwadee Limtharakul Stephen G. Pyne Surat Laphookhieo |
| author_sort | Natnicha Wutthiwong |
| collection | DOAJ |
| description | Daldiniaeschsone A (<b>1</b>), a rare tricyclic polyketide having a chromone unit fused to a <i>δ</i>-lactone and its symmetrical 6,6′-biphenyl dimer, daldiniaeschsone B (<b>2</b>), together with three known compounds (<b>3</b>−<b>5</b>), were isolated from a plant-derived endophytic fungus, <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed <i>α</i>-glucosidase inhibitory activity with IC<sub>50</sub> values ranging from 0.16−0.85 mM and compound <b>1</b> was the best <i>α</i>-glucosidase inhibitory activity (IC<sub>50</sub> = 0.16 mM). |
| first_indexed | 2024-03-10T11:43:59Z |
| format | Article |
| id | doaj.art-10cff413e8ba4befbda4a218e21ba180 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T11:43:59Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-10cff413e8ba4befbda4a218e21ba1802023-11-21T18:12:34ZengMDPI AGJournal of Fungi2309-608X2021-05-017535810.3390/jof7050358Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745Natnicha Wutthiwong0Virayu Suthiphasilp1Aknarin Pintatum2Nakarin Suwannarach3Jaturong Kumla4Saisamorn Lumyong5Tharakorn Maneerat6Rawiwan Charoensup7Sarot Cheenpracha8Thunwadee Limtharakul9Stephen G. Pyne10Surat Laphookhieo11Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandCenter of Chemical Innovation for Sustainability (CIS), School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandCenter of Chemical Innovation for Sustainability (CIS), School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandDepartment of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, ThailandCenter of Chemical Innovation for Sustainability (CIS), School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandMedicinal Plants Innovation Center of Mae Fah Luang University, Chiang Rai 57100, ThailandSchool of Science, University of Phayao, Phayao 56000, ThailandDepartment of Chemistry, Faculty of Science and Research Center on Chemistry for Development of Health Promoting Products from Northern Resources, Chiang Mai University, Chiang Mai 50200, ThailandSchool of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, AustraliaCenter of Chemical Innovation for Sustainability (CIS), School of Science, Mae Fah Luang University, Chiang Rai 57100, ThailandDaldiniaeschsone A (<b>1</b>), a rare tricyclic polyketide having a chromone unit fused to a <i>δ</i>-lactone and its symmetrical 6,6′-biphenyl dimer, daldiniaeschsone B (<b>2</b>), together with three known compounds (<b>3</b>−<b>5</b>), were isolated from a plant-derived endophytic fungus, <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed <i>α</i>-glucosidase inhibitory activity with IC<sub>50</sub> values ranging from 0.16−0.85 mM and compound <b>1</b> was the best <i>α</i>-glucosidase inhibitory activity (IC<sub>50</sub> = 0.16 mM).https://www.mdpi.com/2309-608X/7/5/358<i>Daldinia eschscholtzii</i> SDBR-CMUNKC745tricyclic polyketidebiphenyl dimerchromone<i>α</i>-glucosidase inhibitory activity |
| spellingShingle | Natnicha Wutthiwong Virayu Suthiphasilp Aknarin Pintatum Nakarin Suwannarach Jaturong Kumla Saisamorn Lumyong Tharakorn Maneerat Rawiwan Charoensup Sarot Cheenpracha Thunwadee Limtharakul Stephen G. Pyne Surat Laphookhieo Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 Journal of Fungi <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 tricyclic polyketide biphenyl dimer chromone <i>α</i>-glucosidase inhibitory activity |
| title | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 |
| title_full | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 |
| title_fullStr | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 |
| title_full_unstemmed | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 |
| title_short | Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a <i>δ</i>-Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 |
| title_sort | daldiniaeschsone a a rare tricyclic polyketide having a chromone unit fused to a i δ i lactone and its symmetrical biphenyl dimer daldiniaeschsone b from an endophytic fungus i daldinia eschscholtzii i sdbr cmunkc745 |
| topic | <i>Daldinia eschscholtzii</i> SDBR-CMUNKC745 tricyclic polyketide biphenyl dimer chromone <i>α</i>-glucosidase inhibitory activity |
| url | https://www.mdpi.com/2309-608X/7/5/358 |
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