Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report
BackgroundCryptosporidium infections in humans typically result in symptoms such as abdominal pain and diarrhea. When the diarrhea is severe, it can cause serious complications and even be life-threatening, especially in patients with compromised immune systems.Case presentationHere, we reported the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269963/full |
| _version_ | 1797647597583728640 |
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| author | Xiaoyi Liu Jing Wang Jun Liu Xuming Li Yuanlin Guan Suyun Qian Xinlei Jia |
| author_facet | Xiaoyi Liu Jing Wang Jun Liu Xuming Li Yuanlin Guan Suyun Qian Xinlei Jia |
| author_sort | Xiaoyi Liu |
| collection | DOAJ |
| description | BackgroundCryptosporidium infections in humans typically result in symptoms such as abdominal pain and diarrhea. When the diarrhea is severe, it can cause serious complications and even be life-threatening, especially in patients with compromised immune systems.Case presentationHere, we reported the use of metagenomic next-generation sequencing (mNGS) to assist in the diagnosis and treatment of a 10-year-old boy with severe Cryptosporidium infection. Despite the absence of any history of immunocompromise, the infection still resulted in severe symptoms, including shock, as well as damage to his pancreas and kidneys. The mNGS tests detected the presence of Cryptosporidium parvum when conventional methods failed. The patient received anti-parasite treatment along with supportive care to manage the condition. With disease surveillance based on regular clinical tests and sequential mNGS tests, the child recovered from the severe conditions.ConclusionOur study emphasized the importance of recognizing the potential severity of Cryptosporidium infection, even among individuals with normal immune systems. Timely diagnosis and ongoing monitoring are essential for patient prognosis. |
| first_indexed | 2024-03-11T15:19:47Z |
| format | Article |
| id | doaj.art-10d0e9a76aa546128624232aa8a17de5 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T15:19:47Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-10d0e9a76aa546128624232aa8a17de52023-10-28T21:25:49ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-10-011310.3389/fcimb.2023.12699631269963Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case reportXiaoyi Liu0Jing Wang1Jun Liu2Xuming Li3Yuanlin Guan4Suyun Qian5Xinlei Jia6Pediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaDepartment of Scientific Affairs, Hugobiotech Co., Ltd., Beijing, ChinaPediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaDepartment of Scientific Affairs, Hugobiotech Co., Ltd., Beijing, ChinaDepartment of Scientific Affairs, Hugobiotech Co., Ltd., Beijing, ChinaPediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaPediatric Intensive Care Unit, Beijing Children’s Hospital, Capital Medical University, Beijing, ChinaBackgroundCryptosporidium infections in humans typically result in symptoms such as abdominal pain and diarrhea. When the diarrhea is severe, it can cause serious complications and even be life-threatening, especially in patients with compromised immune systems.Case presentationHere, we reported the use of metagenomic next-generation sequencing (mNGS) to assist in the diagnosis and treatment of a 10-year-old boy with severe Cryptosporidium infection. Despite the absence of any history of immunocompromise, the infection still resulted in severe symptoms, including shock, as well as damage to his pancreas and kidneys. The mNGS tests detected the presence of Cryptosporidium parvum when conventional methods failed. The patient received anti-parasite treatment along with supportive care to manage the condition. With disease surveillance based on regular clinical tests and sequential mNGS tests, the child recovered from the severe conditions.ConclusionOur study emphasized the importance of recognizing the potential severity of Cryptosporidium infection, even among individuals with normal immune systems. Timely diagnosis and ongoing monitoring are essential for patient prognosis.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269963/fullCryptosporidium parvummNGShealthy boyPICUpancreatitis |
| spellingShingle | Xiaoyi Liu Jing Wang Jun Liu Xuming Li Yuanlin Guan Suyun Qian Xinlei Jia Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report Frontiers in Cellular and Infection Microbiology Cryptosporidium parvum mNGS healthy boy PICU pancreatitis |
| title | Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report |
| title_full | Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report |
| title_fullStr | Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report |
| title_full_unstemmed | Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report |
| title_short | Cryptosporidiosis diagnosed using metagenomic next-generation sequencing in a healthy child admitted to pediatric intensive care unit: a case report |
| title_sort | cryptosporidiosis diagnosed using metagenomic next generation sequencing in a healthy child admitted to pediatric intensive care unit a case report |
| topic | Cryptosporidium parvum mNGS healthy boy PICU pancreatitis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1269963/full |
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