Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
Abstract Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistan...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-021-00138-3 |
| _version_ | 1797643035539931136 |
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| author | Rémy Bation Charline Magnin Emmanuel Poulet Marine Mondino Jérôme Brunelin |
| author_facet | Rémy Bation Charline Magnin Emmanuel Poulet Marine Mondino Jérôme Brunelin |
| author_sort | Rémy Bation |
| collection | DOAJ |
| description | Abstract Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistant negative symptoms of schizophrenia (NCT00875498). In a randomized sham-controlled 2-arm study, 22 patients with schizophrenia and treatment-resistant negative symptoms received 20 sessions of either active (n = 12) or sham (n = 10) iTBS. Sessions were delivered twice a day on 10 consecutive working days. Negative symptom severity was assessed 5 times using the Scale for the Assessment of Negative Symptoms (SANS): before iTBS, after iTBS, and 1, 3, and 6 months after iTBS. As a secondary objective, we explored the acute effects of iTBS on functional connectivity of the left dorsolateral prefrontal cortex (DLPFC) using seed-based resting-state functional connectivity MRI (rsFC fMRI) images acquired before and after iTBS. Active iTBS over the left DLPFC significantly decreased negative symptoms severity compared to sham iTBS (F (3,60) = 3.321, p = 0.026). Post hoc analyses revealed that the difference between groups was significant 6 months after the end of stimulation sessions. Neuroimaging revealed an increase in rsFC between the left DLPFC and a brain region encompassing the right lateral occipital cortex and right angular gyrus and a right midbrain region that may encompass dopamine neuron cell bodies. Thus, iTBS over the left DLPFC can alleviate negative symptoms of schizophrenia. The effect might be driven by significant modulation of dopamine transmission. |
| first_indexed | 2024-03-11T14:08:52Z |
| format | Article |
| id | doaj.art-10d25ef312584e709236bc1f7f9c28e6 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-11T14:08:52Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-10d25ef312584e709236bc1f7f9c28e62023-11-02T00:41:56ZengNature Portfolionpj Schizophrenia2334-265X2021-02-01711710.1038/s41537-021-00138-3Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot studyRémy Bation0Charline Magnin1Emmanuel Poulet2Marine Mondino3Jérôme Brunelin4INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 TeamINSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 TeamINSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 TeamINSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 TeamINSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, PSYR2 TeamAbstract Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistant negative symptoms of schizophrenia (NCT00875498). In a randomized sham-controlled 2-arm study, 22 patients with schizophrenia and treatment-resistant negative symptoms received 20 sessions of either active (n = 12) or sham (n = 10) iTBS. Sessions were delivered twice a day on 10 consecutive working days. Negative symptom severity was assessed 5 times using the Scale for the Assessment of Negative Symptoms (SANS): before iTBS, after iTBS, and 1, 3, and 6 months after iTBS. As a secondary objective, we explored the acute effects of iTBS on functional connectivity of the left dorsolateral prefrontal cortex (DLPFC) using seed-based resting-state functional connectivity MRI (rsFC fMRI) images acquired before and after iTBS. Active iTBS over the left DLPFC significantly decreased negative symptoms severity compared to sham iTBS (F (3,60) = 3.321, p = 0.026). Post hoc analyses revealed that the difference between groups was significant 6 months after the end of stimulation sessions. Neuroimaging revealed an increase in rsFC between the left DLPFC and a brain region encompassing the right lateral occipital cortex and right angular gyrus and a right midbrain region that may encompass dopamine neuron cell bodies. Thus, iTBS over the left DLPFC can alleviate negative symptoms of schizophrenia. The effect might be driven by significant modulation of dopamine transmission.https://doi.org/10.1038/s41537-021-00138-3 |
| spellingShingle | Rémy Bation Charline Magnin Emmanuel Poulet Marine Mondino Jérôme Brunelin Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study npj Schizophrenia |
| title | Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study |
| title_full | Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study |
| title_fullStr | Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study |
| title_full_unstemmed | Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study |
| title_short | Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study |
| title_sort | intermittent theta burst stimulation for negative symptoms of schizophrenia a double blind sham controlled pilot study |
| url | https://doi.org/10.1038/s41537-021-00138-3 |
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