Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress

Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress

Abstract Background Metformin is an inhibitor of oxidative phosphorylation that displays an array of anticancer activities. The interference of metformin with the activity of multi-drug resistance systems in cancer cells has been reported. However, the consequences of the acquired chemoresistance fo...

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Bibliographic Details
Main Authors: Jessica Catapano, Marcin Luty, Tomasz Wróbel, Maciej Pudełek, Katarzyna Piwowarczyk, Sylwia Kędracka-Krok, Maciej Siedlar, Zbigniew Madeja, Jarosław Czyż
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cellular & Molecular Biology Letters
Subjects:
Metabolic stress
Drug resistance
Prostate cancer
Metabolic adaptation
Metformin
Online Access:https://doi.org/10.1186/s11658-022-00400-1

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