Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease
Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs interact with a wide range of proteins, including proteases, growth factors, cytokines, chemokines and adhesion molec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.639666/full |
| _version_ | 1818439949891928064 |
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| author | Deling Shi Anran Sheng Lianli Chi |
| author_facet | Deling Shi Anran Sheng Lianli Chi |
| author_sort | Deling Shi |
| collection | DOAJ |
| description | Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs interact with a wide range of proteins, including proteases, growth factors, cytokines, chemokines and adhesion molecules, enabling them to mediate many physiological processes, such as protein function, cellular adhesion and signaling. GAG-protein interactions participate in and intervene in a variety of human diseases, including cardiovascular disease, infectious disease, neurodegenerative diseases and tumors. The breakthrough in analytical tools and approaches during the last two decades has facilitated a greater understanding of the importance of GAG-protein interactions and their roles in human diseases. This review focuses on aspects of the molecular basis and mechanisms of GAG-protein interactions involved in human disease. The most recent advances in analytical tools, especially mass spectrometry-based GAG sequencing and binding motif characterization methods, are introduced. An update of selected families of GAG binding proteins is presented. Perspectives on development of novel therapeutics targeting specific GAG-protein interactions are also covered in this review. |
| first_indexed | 2024-12-14T18:04:36Z |
| format | Article |
| id | doaj.art-10d28327ee9541a4adfc7c16e1076e22 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-14T18:04:36Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-10d28327ee9541a4adfc7c16e1076e222022-12-21T22:52:23ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-03-01810.3389/fmolb.2021.639666639666Glycosaminoglycan-Protein Interactions and Their Roles in Human DiseaseDeling ShiAnran ShengLianli ChiGlycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs interact with a wide range of proteins, including proteases, growth factors, cytokines, chemokines and adhesion molecules, enabling them to mediate many physiological processes, such as protein function, cellular adhesion and signaling. GAG-protein interactions participate in and intervene in a variety of human diseases, including cardiovascular disease, infectious disease, neurodegenerative diseases and tumors. The breakthrough in analytical tools and approaches during the last two decades has facilitated a greater understanding of the importance of GAG-protein interactions and their roles in human diseases. This review focuses on aspects of the molecular basis and mechanisms of GAG-protein interactions involved in human disease. The most recent advances in analytical tools, especially mass spectrometry-based GAG sequencing and binding motif characterization methods, are introduced. An update of selected families of GAG binding proteins is presented. Perspectives on development of novel therapeutics targeting specific GAG-protein interactions are also covered in this review.https://www.frontiersin.org/articles/10.3389/fmolb.2021.639666/fullglycosaminoglycanproteinhuman diseaseinteractionmolecular recognition |
| spellingShingle | Deling Shi Anran Sheng Lianli Chi Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease Frontiers in Molecular Biosciences glycosaminoglycan protein human disease interaction molecular recognition |
| title | Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease |
| title_full | Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease |
| title_fullStr | Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease |
| title_full_unstemmed | Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease |
| title_short | Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease |
| title_sort | glycosaminoglycan protein interactions and their roles in human disease |
| topic | glycosaminoglycan protein human disease interaction molecular recognition |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.639666/full |
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