Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis
Abstract Background Previous research has already indicated an elevated risk of breast cancer (BC) among survivors of malignant lymphoma, but the underlying reasons remain unknown. Our objective is to elucidate the causal relationship between malignant lymphoma and BC through Mendelian randomization...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Genomic Data |
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| Online Access: | https://doi.org/10.1186/s12863-023-01162-1 |
| _version_ | 1797556070548242432 |
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| author | Xiong Chen GuoHuang Hu |
| author_facet | Xiong Chen GuoHuang Hu |
| author_sort | Xiong Chen |
| collection | DOAJ |
| description | Abstract Background Previous research has already indicated an elevated risk of breast cancer (BC) among survivors of malignant lymphoma, but the underlying reasons remain unknown. Our objective is to elucidate the causal relationship between malignant lymphoma and BC through Mendelian randomization (MR). Genome-wide association studies (GWAS) data from 181,125 Hodgkin lymphoma (HL) patients and 181,289 non-Hodgkin lymphoma (NHL) patients from the FinnGen Consortium were utilized as exposure. We selected single nucleotide polymorphisms (SNPs) strongly associated with the exposure as instrumental variables to investigate their relationship with BC in a cohort of 107,722 participants. Subsequently, we obtained data from the UK Biobank containing gender-stratified information on HL, NHL, and BC. We validated the findings from our analysis and explored the impact of gender. The Inverse-Variance Weighted (IVW) method served as the primary reference for the two-sample MR, accompanied by tests for heterogeneity and pleiotropy. Results The analysis results from the FinnGen consortium indicate that there is no causal relationship between HL and NHL with BC. HL (OR = 1.01, 95% CI = 0.98–1.04, p = 0.29), NHL (OR = 1.01, 95% CI = 0.96–1.05, p = 0.64). When utilizing GWAS data from the UK Biobank that includes different gender cohorts, the lack of association between HL, NHL, and BC remains consistent. HL (OR = 1.08, 95% CI = 0.74–1.56, p = 0.69), HL-Female (OR = 0.84, 95% CI = 0.59–1.19, p = 0.33), NHL (OR = 0.89, 95% CI = 0.66–1.19, p = 0.44), and NHL-Female (OR = 0.81, 95% CI = 0.58–1.11, p = 0.18). Conclusions The two-sample MR analysis indicates that there is no significant causal relationship between malignant lymphoma (HL and NHL) and BC. The association between malignant lymphoma and breast cancer requires further in-depth research and exploration. |
| first_indexed | 2024-03-10T16:57:33Z |
| format | Article |
| id | doaj.art-10d29e4b36ec478087539d6f0d31445b |
| institution | Directory Open Access Journal |
| issn | 2730-6844 |
| language | English |
| last_indexed | 2024-03-10T16:57:33Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomic Data |
| spelling | doaj.art-10d29e4b36ec478087539d6f0d31445b2023-11-20T11:05:12ZengBMCBMC Genomic Data2730-68442023-10-012411710.1186/s12863-023-01162-1Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysisXiong Chen0GuoHuang Hu1Department of General Surgery, Affiliated Changsha Hospital of Hunan Normal UniversityDepartment of General Surgery, Affiliated Changsha Hospital of Hunan Normal UniversityAbstract Background Previous research has already indicated an elevated risk of breast cancer (BC) among survivors of malignant lymphoma, but the underlying reasons remain unknown. Our objective is to elucidate the causal relationship between malignant lymphoma and BC through Mendelian randomization (MR). Genome-wide association studies (GWAS) data from 181,125 Hodgkin lymphoma (HL) patients and 181,289 non-Hodgkin lymphoma (NHL) patients from the FinnGen Consortium were utilized as exposure. We selected single nucleotide polymorphisms (SNPs) strongly associated with the exposure as instrumental variables to investigate their relationship with BC in a cohort of 107,722 participants. Subsequently, we obtained data from the UK Biobank containing gender-stratified information on HL, NHL, and BC. We validated the findings from our analysis and explored the impact of gender. The Inverse-Variance Weighted (IVW) method served as the primary reference for the two-sample MR, accompanied by tests for heterogeneity and pleiotropy. Results The analysis results from the FinnGen consortium indicate that there is no causal relationship between HL and NHL with BC. HL (OR = 1.01, 95% CI = 0.98–1.04, p = 0.29), NHL (OR = 1.01, 95% CI = 0.96–1.05, p = 0.64). When utilizing GWAS data from the UK Biobank that includes different gender cohorts, the lack of association between HL, NHL, and BC remains consistent. HL (OR = 1.08, 95% CI = 0.74–1.56, p = 0.69), HL-Female (OR = 0.84, 95% CI = 0.59–1.19, p = 0.33), NHL (OR = 0.89, 95% CI = 0.66–1.19, p = 0.44), and NHL-Female (OR = 0.81, 95% CI = 0.58–1.11, p = 0.18). Conclusions The two-sample MR analysis indicates that there is no significant causal relationship between malignant lymphoma (HL and NHL) and BC. The association between malignant lymphoma and breast cancer requires further in-depth research and exploration.https://doi.org/10.1186/s12863-023-01162-1Breast cancerMalignant lymphomaGenderMendelian randomizationHodgkin disease |
| spellingShingle | Xiong Chen GuoHuang Hu Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis BMC Genomic Data Breast cancer Malignant lymphoma Gender Mendelian randomization Hodgkin disease |
| title | Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis |
| title_full | Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis |
| title_fullStr | Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis |
| title_full_unstemmed | Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis |
| title_short | Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis |
| title_sort | correlation study of malignant lymphoma and breast cancer in different gender european populations mendelian randomization analysis |
| topic | Breast cancer Malignant lymphoma Gender Mendelian randomization Hodgkin disease |
| url | https://doi.org/10.1186/s12863-023-01162-1 |
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