Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice
Acute vestibular syndrome (AVS) is characterized by severe posturo-locomotor and vestibulo-oculomotor impairment and accompanies several types of peripheral vestibulopathies (PVP). We know very little about its etiology, how its various symptoms are expressed and how it evolves with age. Robust repa...
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00462/full |
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| author | Raphaelle Cassel Sylvette Wiener-Vacher A. El Ahmadi Brahim Tighilet Christian Chabbert |
| author_facet | Raphaelle Cassel Sylvette Wiener-Vacher A. El Ahmadi Brahim Tighilet Christian Chabbert |
| author_sort | Raphaelle Cassel |
| collection | DOAJ |
| description | Acute vestibular syndrome (AVS) is characterized by severe posturo-locomotor and vestibulo-oculomotor impairment and accompanies several types of peripheral vestibulopathies (PVP). We know very little about its etiology, how its various symptoms are expressed and how it evolves with age. Robust repair capabilities of primary vestibular synapses have recently been shown to restore behavioral functionality. In this study, we used a mouse model of an excitotoxically induced unilateral vestibular lesion to compare the ability to restore balance and posture between old and young adult mice. We compared the temporal evolution of the evoked vestibular syndrome using a battery of behavioral tests to follow the evolution of postural-locomotor alterations and equilibrium. For the first time, we show that young adult (3 months) and elderly (22 months) mice are together able to restore normal postural-locomotor function following transient unilateral excitotoxic vestibular insult, though with different time courses. This animal study paves way for future, more detailed studies of how the early postural and locomotor disturbances following a unilateral insult are compensated for by various plasticity mechanisms, and in particular how age influences these mechanisms. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T07:07:28Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-10d3980c19ec44a7878450297468831f2022-12-22T00:33:42ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-06-01910.3389/fneur.2018.00462365717Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly MiceRaphaelle Cassel0Sylvette Wiener-Vacher1A. El Ahmadi2Brahim Tighilet3Christian Chabbert4Laboratoire de Neurosciences Sensorielles et Cognitives - Equipe physiopathologie et Thérapie des Désordres Vestibulaire, Centre National de la Recherche Scientifique, Aix Marseille Université, UMR 7260, Marseille, FranceLaboratoire d'Exploration Fonctionnel de l'Équilibre chez l'Enfant, APHP, Université Paris VII, Paris, FranceLaboratoire de Neurosciences Sensorielles et Cognitives - Equipe physiopathologie et Thérapie des Désordres Vestibulaire, Centre National de la Recherche Scientifique, Aix Marseille Université, UMR 7260, Marseille, FranceLaboratoire de Neurosciences Sensorielles et Cognitives - Equipe physiopathologie et Thérapie des Désordres Vestibulaire, Centre National de la Recherche Scientifique, Aix Marseille Université, UMR 7260, Marseille, FranceLaboratoire de Neurosciences Sensorielles et Cognitives - Equipe physiopathologie et Thérapie des Désordres Vestibulaire, Centre National de la Recherche Scientifique, Aix Marseille Université, UMR 7260, Marseille, FranceAcute vestibular syndrome (AVS) is characterized by severe posturo-locomotor and vestibulo-oculomotor impairment and accompanies several types of peripheral vestibulopathies (PVP). We know very little about its etiology, how its various symptoms are expressed and how it evolves with age. Robust repair capabilities of primary vestibular synapses have recently been shown to restore behavioral functionality. In this study, we used a mouse model of an excitotoxically induced unilateral vestibular lesion to compare the ability to restore balance and posture between old and young adult mice. We compared the temporal evolution of the evoked vestibular syndrome using a battery of behavioral tests to follow the evolution of postural-locomotor alterations and equilibrium. For the first time, we show that young adult (3 months) and elderly (22 months) mice are together able to restore normal postural-locomotor function following transient unilateral excitotoxic vestibular insult, though with different time courses. This animal study paves way for future, more detailed studies of how the early postural and locomotor disturbances following a unilateral insult are compensated for by various plasticity mechanisms, and in particular how age influences these mechanisms.https://www.frontiersin.org/article/10.3389/fneur.2018.00462/fullacute vestibular syndromeequilibrium impairmentvestibular deafferentationbehavioral evaluationmouse model |
| spellingShingle | Raphaelle Cassel Sylvette Wiener-Vacher A. El Ahmadi Brahim Tighilet Christian Chabbert Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice Frontiers in Neurology acute vestibular syndrome equilibrium impairment vestibular deafferentation behavioral evaluation mouse model |
| title | Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice |
| title_full | Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice |
| title_fullStr | Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice |
| title_full_unstemmed | Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice |
| title_short | Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice |
| title_sort | reduced balance restoration capacities following unilateral vestibular insult in elderly mice |
| topic | acute vestibular syndrome equilibrium impairment vestibular deafferentation behavioral evaluation mouse model |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00462/full |
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