CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.

CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.

Genomic imprints-parental allele-specific DNA methylation marks at the differentially methylated regions (DMRs) of imprinted genes-are erased and reestablished in germ cells according to the individual's sex. Imprint establishment at paternally methylated germ line DMRs occurs in fetal male ger...

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Bibliographic Details
Main Authors: Dong-Hoon Lee, Purnima Singh, Shirley Y Tsai, Nathan Oates, Alexander Spalla, Claudio Spalla, Lucy Brown, Guillermo Rivas, Garrett Larson, Tibor A Rauch, Gerd P Pfeifer, Piroska E Szabó
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2991272?pdf=render

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