Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity

Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity

Mycolactone is an exotoxin produced by <i>Mycobacterium ulcerans</i> that causes the neglected tropical skin disease Buruli ulcer. This toxin inhibits the Sec61 translocon in the endoplasmic reticulum (ER), preventing the host cell from producing several secretory and transmembrane prote...

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Bibliographic Details
Main Authors: John D. M. Nguyen, Gabriel C. A. da Hora, Jessica M. J. Swanson
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Toxins
Subjects:
mycolactone
Buruli ulcer
ER membrane
Sec61 translocon
molecular dynamics
membrane permeation
Online Access:https://www.mdpi.com/2072-6651/15/8/486

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