Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions

Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions

Abstract Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor, nonalcoholic fatty liver disease (NAFLD) are an unmet health issue due to widespread obesity. We assessed copy number changes of genes associated with hepatocarcinogenesis and oxidative pathways at...

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Bibliographic Details
Main Authors: Juliane Friemel, Irianna Torres, Elizabeth Brauneis, Tim Thörner, Alejandro A. Schäffer, E. Michael Gertz, Tobias Grob, Kati Seidl, Achim Weber, Thomas Ried, Kerstin Heselmeyer-Haddad
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-27173-z

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