正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究
Abstract Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for a considerable proportion of type 2 diabetes patients. The aim of this research was to investigate the epidemiological and clinical characteristics of normoalbuminuric kidney dise...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13230 |
| _version_ | 1828118601365716992 |
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| author | Xiaomeng Jia Li Zang Ping Pang Lina Jiang Jin Du Weijun Gu Jianming Ba Yiming Mu Zhaohui Lyu |
| author_facet | Xiaomeng Jia Li Zang Ping Pang Lina Jiang Jin Du Weijun Gu Jianming Ba Yiming Mu Zhaohui Lyu |
| author_sort | Xiaomeng Jia |
| collection | DOAJ |
| description | Abstract Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for a considerable proportion of type 2 diabetes patients. The aim of this research was to investigate the epidemiological and clinical characteristics of normoalbuminuric kidney disease in a Chinese population. Methods We included 8131 diabetic patients from a multicenter prospective study in China. Based on eGFR and urinary albumin‐to‐creatinine ratio (UACR), participants were stratified into four groups—normal albuminuria, albuminuria, normoalbuminuria with eGFR < 60 mL/min/1.73 m2, and albuminuria with eGFR < 60 mL/min/1.73 m2. Clinical parameters and characteristics of patients with normoalbuminuria and eGFR < 60 mL/min/1.73 m2 were retrospectively analyzed. Results A total of 1060 out of 8131 individuals with diabetes had decreased eGFR (<60 mL/min/1.73 m2). Normoalbuminuria accounted for 63.3% of participants with eGFR < 60 mL/min/1.73 m2, and microalbuminuria and macroalbuminuria accounted for 30.1% and 6.3%, respectively. Patients with normoalbuminuria and reduced eGFR were more frequently male, older, and had higher levels of triglycerides than patients with normal albuminuria and eGFR. We also detected a correlation between lower extremity arterial disease, newly diagnosed diabetes, and normoalbuminuria‐reduced eGFR. Compared with participants with both albuminuria and eGFR decline, those with normoalbuminuria had better metabolic indicators, including systolic blood pressure and glycosylated hemoglobin, and shorter diabetes duration. Even in the normal range, UACR has a significant correlation with the risk of eGFR insufficiency. Conclusions Normoalbuminuric renal insufficiency, characterized by male sex, older age, a higher level of triglyceride levels, and a higher risk of lower extremity arterial disease, accounted for a dominant proportion of diabetic patients with eGFR decline. |
| first_indexed | 2024-04-11T13:33:57Z |
| format | Article |
| id | doaj.art-10d721eb39854e36a045ab8c74f052ac |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-11T13:33:57Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-10d721eb39854e36a045ab8c74f052ac2022-12-22T04:21:37ZengWileyJournal of Diabetes1753-03931753-04072022-01-01141152510.1111/1753-0407.13230正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究Xiaomeng Jia0Li Zang1Ping Pang2Lina Jiang3Jin Du4Weijun Gu5Jianming Ba6Yiming Mu7Zhaohui Lyu8Center for Endocrine Metabolism and Immune Disease, Beijing Luhe Hospital Capital Medical University Beijing ChinaDepartment of Endocrinology Chinese PLA General Hospital Beijing ChinaDepartment of Endocrinology Hainan Branch of PLA General Hospital Sanya ChinaThe People's Liberation Army Troop Zhang Jiakou ChinaDepartment of Endocrinology Chinese PLA General Hospital Beijing ChinaDepartment of Endocrinology Chinese PLA General Hospital Beijing ChinaDepartment of Endocrinology Chinese PLA General Hospital Beijing ChinaDepartment of Endocrinology Chinese PLA General Hospital Beijing ChinaDepartment of Endocrinology Chinese PLA General Hospital Beijing ChinaAbstract Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for a considerable proportion of type 2 diabetes patients. The aim of this research was to investigate the epidemiological and clinical characteristics of normoalbuminuric kidney disease in a Chinese population. Methods We included 8131 diabetic patients from a multicenter prospective study in China. Based on eGFR and urinary albumin‐to‐creatinine ratio (UACR), participants were stratified into four groups—normal albuminuria, albuminuria, normoalbuminuria with eGFR < 60 mL/min/1.73 m2, and albuminuria with eGFR < 60 mL/min/1.73 m2. Clinical parameters and characteristics of patients with normoalbuminuria and eGFR < 60 mL/min/1.73 m2 were retrospectively analyzed. Results A total of 1060 out of 8131 individuals with diabetes had decreased eGFR (<60 mL/min/1.73 m2). Normoalbuminuria accounted for 63.3% of participants with eGFR < 60 mL/min/1.73 m2, and microalbuminuria and macroalbuminuria accounted for 30.1% and 6.3%, respectively. Patients with normoalbuminuria and reduced eGFR were more frequently male, older, and had higher levels of triglycerides than patients with normal albuminuria and eGFR. We also detected a correlation between lower extremity arterial disease, newly diagnosed diabetes, and normoalbuminuria‐reduced eGFR. Compared with participants with both albuminuria and eGFR decline, those with normoalbuminuria had better metabolic indicators, including systolic blood pressure and glycosylated hemoglobin, and shorter diabetes duration. Even in the normal range, UACR has a significant correlation with the risk of eGFR insufficiency. Conclusions Normoalbuminuric renal insufficiency, characterized by male sex, older age, a higher level of triglyceride levels, and a higher risk of lower extremity arterial disease, accounted for a dominant proportion of diabetic patients with eGFR decline.https://doi.org/10.1111/1753-0407.132302型糖尿病糖尿病肾病正常蛋白尿糖尿病并发症 |
| spellingShingle | Xiaomeng Jia Li Zang Ping Pang Lina Jiang Jin Du Weijun Gu Jianming Ba Yiming Mu Zhaohui Lyu 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究 Journal of Diabetes 2型糖尿病 糖尿病肾病 正常蛋白尿 糖尿病并发症 |
| title | 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究 |
| title_full | 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究 |
| title_fullStr | 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究 |
| title_full_unstemmed | 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究 |
| title_short | 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究:基于中国人群的多中心研究 |
| title_sort | 正常蛋白尿的2型糖尿病患者肾功能不全状况的研究 基于中国人群的多中心研究 |
| topic | 2型糖尿病 糖尿病肾病 正常蛋白尿 糖尿病并发症 |
| url | https://doi.org/10.1111/1753-0407.13230 |
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