Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it coul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-03-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483800/?tool=EBI |
| _version_ | 1818573567132958720 |
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| author | Fernanda M Cerqueira Francisco R M Laurindo Alicia J Kowaltowski |
| author_facet | Fernanda M Cerqueira Francisco R M Laurindo Alicia J Kowaltowski |
| author_sort | Fernanda M Cerqueira |
| collection | DOAJ |
| description | Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis. |
| first_indexed | 2024-12-15T00:13:04Z |
| format | Article |
| id | doaj.art-10d992073ec84d959a6f5f3f207035c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:13:04Z |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-10d992073ec84d959a6f5f3f207035c52022-12-21T22:42:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-03-0163e1843310.1371/journal.pone.0018433Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.Fernanda M CerqueiraFrancisco R M LaurindoAlicia J KowaltowskiEnhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483800/?tool=EBI |
| spellingShingle | Fernanda M Cerqueira Francisco R M Laurindo Alicia J Kowaltowski Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. PLoS ONE |
| title | Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. |
| title_full | Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. |
| title_fullStr | Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. |
| title_full_unstemmed | Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. |
| title_short | Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis. |
| title_sort | mild mitochondrial uncoupling and calorie restriction increase fasting enos akt and mitochondrial biogenesis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483800/?tool=EBI |
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