Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS

Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is a recessively inherited disease characterized by early onset dementia associated with bone cysts. Our group has recently established the molecular background of PLOSL by identifying mutations in DAP12 and TREM2 g...

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Bibliographic Details
Main Authors: Anna Kiialainen, Karine Hovanes, Juha Paloneva, Outi Kopra, Leena Peltonen
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Innate immunity
Microglia
Activating receptor
DAP12
TREM2
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002153

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