Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina
Objective. To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study. Methods. Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of Escherichia...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Pan American Health Organization
2021-07-01
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| Series: | Revista Panamericana de Salud Pública |
| Subjects: | |
| Online Access: | https://iris.paho.org/handle/10665.2/54532 |
| _version_ | 1818656591562407936 |
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| author | Silvia Boni Gustavo H. Marin Laura Campaña Lupe Marin Alejandra Corso Soledad Risso-Patron Fernanda Gabriel Valeria Garay Manuel Limeres |
| author_facet | Silvia Boni Gustavo H. Marin Laura Campaña Lupe Marin Alejandra Corso Soledad Risso-Patron Fernanda Gabriel Valeria Garay Manuel Limeres |
| author_sort | Silvia Boni |
| collection | DOAJ |
| description | Objective. To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study.
Methods. Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of Escherichia coli, Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus to beta-lactams was recorded. Resistance/consumption ratio was estimated calculating R for each region of Argentina, and this data was compared with other countries.
Results. The most widely consumed beta-lactams in Argentina were amoxicillin (3.64) for the penicillin sub-group, cephalexin (0.786) for first generation cephalosporins, cefuroxime (0.022) for second generation; cefixime (0.043) for third generation and cefepime (0.0001) for the fourth generation group. Comparison between beta-lactams consumption and bacterial resistance demonstrated great disparities between the six regions of the country.
Conclusions. The case-study of Argentina shows that antimicrobial consumption and resistance of the most common pathogens differed among regions, reflecting different realities within the same country. Because this situation might also be occurring in other countries, this data should be taken into account to target local efforts towards better antimicrobial use, to improve antimicrobial stewardship programs and to propose more suitable sales strategies in order to prevent and control antimicrobial resistance. |
| first_indexed | 2024-12-17T03:28:01Z |
| format | Article |
| id | doaj.art-10dab22ca40944ff8e6019afe8ebb8a8 |
| institution | Directory Open Access Journal |
| issn | 1020-4989 1680-5348 |
| language | English |
| last_indexed | 2024-12-17T03:28:01Z |
| publishDate | 2021-07-01 |
| publisher | Pan American Health Organization |
| record_format | Article |
| series | Revista Panamericana de Salud Pública |
| spelling | doaj.art-10dab22ca40944ff8e6019afe8ebb8a82022-12-21T22:05:21ZengPan American Health OrganizationRevista Panamericana de Salud Pública1020-49891680-53482021-07-01457611110.26633/RPSP.2021.76rpspDisparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in ArgentinaSilvia Boni0Gustavo H. MarinLaura Campaña1Lupe Marin2Alejandra Corso3Soledad Risso-Patron4Fernanda Gabriel5Valeria Garay6Manuel Limeres7National Administration of Drugs, Food and Technology, Buenos Aires, ArgentinaNational Administration of Drugs, Food and Technology, Buenos Aires, ArgentinaNational University La Plata-CUFAR-CONICET, La Plata, ArgentinaMinistry of Health, Buenos Aires, ArgentinaNational Administration of Drugs, Food and Technology, Buenos Aires, ArgentinaNational Administration of Drugs, Food and Technology, Buenos Aires, ArgentinaNational Administration of Drugs, Food and Technology, Buenos Aires, ArgentinaNational Administration of Drugs, Food and Technology, Buenos Aires, ArgentinaObjective. To describe bacterial resistance and antimicrobial consumption ratio at the subnational level in Argentina during 2018, considering beta-lactams group as a case-study. Methods. Antimicrobial consumption was expressed as defined daily doses (DDD)/1000 inhabitants. Resistance of Escherichia coli, Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus to beta-lactams was recorded. Resistance/consumption ratio was estimated calculating R for each region of Argentina, and this data was compared with other countries. Results. The most widely consumed beta-lactams in Argentina were amoxicillin (3.64) for the penicillin sub-group, cephalexin (0.786) for first generation cephalosporins, cefuroxime (0.022) for second generation; cefixime (0.043) for third generation and cefepime (0.0001) for the fourth generation group. Comparison between beta-lactams consumption and bacterial resistance demonstrated great disparities between the six regions of the country. Conclusions. The case-study of Argentina shows that antimicrobial consumption and resistance of the most common pathogens differed among regions, reflecting different realities within the same country. Because this situation might also be occurring in other countries, this data should be taken into account to target local efforts towards better antimicrobial use, to improve antimicrobial stewardship programs and to propose more suitable sales strategies in order to prevent and control antimicrobial resistance.https://iris.paho.org/handle/10665.2/54532drug resistance, microbialbeta-lactamsargentina |
| spellingShingle | Silvia Boni Gustavo H. Marin Laura Campaña Lupe Marin Alejandra Corso Soledad Risso-Patron Fernanda Gabriel Valeria Garay Manuel Limeres Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina Revista Panamericana de Salud Pública drug resistance, microbial beta-lactams argentina |
| title | Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina |
| title_full | Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina |
| title_fullStr | Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina |
| title_full_unstemmed | Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina |
| title_short | Disparities in antimicrobial consumption and resistance within a country: the case of beta-lactams in Argentina |
| title_sort | disparities in antimicrobial consumption and resistance within a country the case of beta lactams in argentina |
| topic | drug resistance, microbial beta-lactams argentina |
| url | https://iris.paho.org/handle/10665.2/54532 |
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