Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response.
<h4>Background</h4>Although constipation has been researched in various neurological disorders, including Parkinson's disease (PD) and spinal cord injury (SCI), the pathological mechanism of this symptom has not been investigated in Alzheimer's disease (AD) associated with loss...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0215205 |
| _version_ | 1818729778877825024 |
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| author | Ji Eun Kim Jin Ju Park Mi Rim Lee Jun Young Choi Bo Ram Song Ji Won Park Mi Ju Kang Hong Joo Son Jin Tae Hong Dae Youn Hwang |
| author_facet | Ji Eun Kim Jin Ju Park Mi Rim Lee Jun Young Choi Bo Ram Song Ji Won Park Mi Ju Kang Hong Joo Son Jin Tae Hong Dae Youn Hwang |
| author_sort | Ji Eun Kim |
| collection | DOAJ |
| description | <h4>Background</h4>Although constipation has been researched in various neurological disorders, including Parkinson's disease (PD) and spinal cord injury (SCI), the pathological mechanism of this symptom has not been investigated in Alzheimer's disease (AD) associated with loss of nerve cells in the brain. This study was undertaken to gain scientific evidences for a molecular correlation between constipation and AD.<h4>Methods</h4>To understand the etiology, we measured alterations in various constipation parameters, muscarinic acetylcholine receptors (mAChRs) and endoplasmic reticulum (ER) stress response, in 11-month-old Tg2576 transgenic (Tg) mice showing AD-like phenotypes.<h4>Results</h4>A high accumulation of amyloid beta (Aβ) peptides, a key marker of AD pathology, were detected in the cortex and hippocampus of Tg mice. Furthermore, significant alterations were observed in various constipation parameters including stool weight, histological structure, cytological structure and mucin secretion in Tg2576 mice. Moreover, M2 and M3 expression and the downstream signaling pathways of mAChRs were decreased in the Tg group, as compared with non-Tg (NT) group. Furthermore, activation of ER stress proteins and alteration of ER structure were also detected in the same group.<h4>Conclusions</h4>The results of the present study provide strong novel evidence that the neuropathological constipation detected in Tg2576 mice is linked to dysregulation of the mAChR signaling pathways and ER stress response. |
| first_indexed | 2024-12-17T22:51:18Z |
| format | Article |
| id | doaj.art-10dadd69d9004ca0a8d07c3a8162e3ae |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T22:51:18Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-10dadd69d9004ca0a8d07c3a8162e3ae2022-12-21T21:29:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01144e021520510.1371/journal.pone.0215205Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response.Ji Eun KimJin Ju ParkMi Rim LeeJun Young ChoiBo Ram SongJi Won ParkMi Ju KangHong Joo SonJin Tae HongDae Youn Hwang<h4>Background</h4>Although constipation has been researched in various neurological disorders, including Parkinson's disease (PD) and spinal cord injury (SCI), the pathological mechanism of this symptom has not been investigated in Alzheimer's disease (AD) associated with loss of nerve cells in the brain. This study was undertaken to gain scientific evidences for a molecular correlation between constipation and AD.<h4>Methods</h4>To understand the etiology, we measured alterations in various constipation parameters, muscarinic acetylcholine receptors (mAChRs) and endoplasmic reticulum (ER) stress response, in 11-month-old Tg2576 transgenic (Tg) mice showing AD-like phenotypes.<h4>Results</h4>A high accumulation of amyloid beta (Aβ) peptides, a key marker of AD pathology, were detected in the cortex and hippocampus of Tg mice. Furthermore, significant alterations were observed in various constipation parameters including stool weight, histological structure, cytological structure and mucin secretion in Tg2576 mice. Moreover, M2 and M3 expression and the downstream signaling pathways of mAChRs were decreased in the Tg group, as compared with non-Tg (NT) group. Furthermore, activation of ER stress proteins and alteration of ER structure were also detected in the same group.<h4>Conclusions</h4>The results of the present study provide strong novel evidence that the neuropathological constipation detected in Tg2576 mice is linked to dysregulation of the mAChR signaling pathways and ER stress response.https://doi.org/10.1371/journal.pone.0215205 |
| spellingShingle | Ji Eun Kim Jin Ju Park Mi Rim Lee Jun Young Choi Bo Ram Song Ji Won Park Mi Ju Kang Hong Joo Son Jin Tae Hong Dae Youn Hwang Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response. PLoS ONE |
| title | Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response. |
| title_full | Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response. |
| title_fullStr | Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response. |
| title_full_unstemmed | Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response. |
| title_short | Constipation in Tg2576 mice model for Alzheimer's disease associated with dysregulation of mechanism involving the mAChR signaling pathway and ER stress response. |
| title_sort | constipation in tg2576 mice model for alzheimer s disease associated with dysregulation of mechanism involving the machr signaling pathway and er stress response |
| url | https://doi.org/10.1371/journal.pone.0215205 |
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