Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus

Abstract Background Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting alterations in DNA methylation (DNAm) of important regulatory genes of the st...

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Main Authors: Tobias Wiechmann, Simone Röh, Susann Sauer, Darina Czamara, Janine Arloth, Maik Ködel, Madita Beintner, Lisanne Knop, Andreas Menke, Elisabeth B. Binder, Nadine Provençal
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
FKBP5
Glucocorticoid receptor
Early-life stress
Targeted bisulfite sequencing
Dexamethasone
Online Access:http://link.springer.com/article/10.1186/s13148-019-0682-5

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