Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions
Photodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a phot...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/8/2075 |
| _version_ | 1797583460279255040 |
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| author | José Francisco Algorri José Miguel López-Higuera Luís Rodríguez-Cobo Adolfo Cobo |
| author_facet | José Francisco Algorri José Miguel López-Higuera Luís Rodríguez-Cobo Adolfo Cobo |
| author_sort | José Francisco Algorri |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a photosensitizer (PS) and visible light to create cytotoxic reactive oxygen species, which can damage cellular organelles and trigger cell death. The foundations of modern photodynamic therapy began in the late 19th and early 20th centuries, and in recent times, it has gained more attention due to the development of new sources and PSs. This review focuses on the latest advancements in light technology for PDT in treating skin cancer lesions. It discusses recent research and developments in light-emitting technologies, their potential benefits and drawbacks, and their implications for clinical practice. Finally, this review summarizes key findings and discusses their implications for the use of PDT in skin cancer treatment, highlighting the limitations of current approaches and providing insights into future research directions to improve both the efficacy and safety of PDT. This review aims to provide a comprehensive understanding of PDT for skin cancer treatment, covering various aspects ranging from the underlying mechanisms to the latest technological advancements in the field. |
| first_indexed | 2024-03-10T23:39:14Z |
| format | Article |
| id | doaj.art-10dc04bed4874a3caca970380e221b00 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T23:39:14Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-10dc04bed4874a3caca970380e221b002023-11-19T02:36:23ZengMDPI AGPharmaceutics1999-49232023-08-01158207510.3390/pharmaceutics15082075Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer LesionsJosé Francisco Algorri0José Miguel López-Higuera1Luís Rodríguez-Cobo2Adolfo Cobo3Photonics Engineering Group, University of Cantabria, 39005 Santander, SpainPhotonics Engineering Group, University of Cantabria, 39005 Santander, SpainCIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, SpainPhotonics Engineering Group, University of Cantabria, 39005 Santander, SpainPhotodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a photosensitizer (PS) and visible light to create cytotoxic reactive oxygen species, which can damage cellular organelles and trigger cell death. The foundations of modern photodynamic therapy began in the late 19th and early 20th centuries, and in recent times, it has gained more attention due to the development of new sources and PSs. This review focuses on the latest advancements in light technology for PDT in treating skin cancer lesions. It discusses recent research and developments in light-emitting technologies, their potential benefits and drawbacks, and their implications for clinical practice. Finally, this review summarizes key findings and discusses their implications for the use of PDT in skin cancer treatment, highlighting the limitations of current approaches and providing insights into future research directions to improve both the efficacy and safety of PDT. This review aims to provide a comprehensive understanding of PDT for skin cancer treatment, covering various aspects ranging from the underlying mechanisms to the latest technological advancements in the field.https://www.mdpi.com/1999-4923/15/8/2075photodynamic therapyskin cancerreactive oxygen species (ROS)wearable medicinelight-emitting materialstextile diffusers |
| spellingShingle | José Francisco Algorri José Miguel López-Higuera Luís Rodríguez-Cobo Adolfo Cobo Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions Pharmaceutics photodynamic therapy skin cancer reactive oxygen species (ROS) wearable medicine light-emitting materials textile diffusers |
| title | Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions |
| title_full | Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions |
| title_fullStr | Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions |
| title_full_unstemmed | Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions |
| title_short | Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions |
| title_sort | advanced light source technologies for photodynamic therapy of skin cancer lesions |
| topic | photodynamic therapy skin cancer reactive oxygen species (ROS) wearable medicine light-emitting materials textile diffusers |
| url | https://www.mdpi.com/1999-4923/15/8/2075 |
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