The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders

The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders

Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or...

Full description

Bibliographic Details
Main Authors:	Paulina Pawelec, Malgorzata Ziemka-Nalecz, Joanna Sypecka, Teresa Zalewska
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	Cells
Subjects:	fractalkine CX3CR1 cerebral ischemia epilepsy neurodegenerative diseases Alzheimer’s disease
Online Access:	https://www.mdpi.com/2073-4409/9/10/2277

Similar Items

The role of the CX3CL1/CX3CR1 axis as potential inflammatory biomarkers in subjects with periodontitis and rheumatoid arthritis: A systematic review
by: Mario A. Alarcón‐Sánchez, et al.
Published: (2024-02-01)

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1
by: Christine Lehner, et al.
Published: (2019-12-01)

Fractalkine/CX3CR1 axis is critical for neuroprotection induced by hypoxic postconditioning against cerebral ischemic injury
by: Lixuan Zhan, et al.
Published: (2024-09-01)

Triptolide alleviates cerebral ischemia/reperfusion injury via regulating the Fractalkine/CX3CR1 signaling pathway
by: Jiajun Zhou, et al.
Published: (2024-06-01)

Defective microglial development in the hippocampus of Cx3cr1 deficient mice
by: Francesca ePagani, et al.
Published: (2015-03-01)

The Fractalkine‐CX3CR1 Axis Regulates Non‐inflammatory Osteoclastogenesis by Enhancing Precursor Cell Survival
by: Yoshikazu Kuboi, et al.
Published: (2022-10-01)

Fractalkine/CX<sub>3</sub>CR1 in Dilated Cardiomyopathy: A Potential Future Target for Immunomodulatory Therapy?
by: Visvesh Jeyalan, et al.
Published: (2023-09-01)

Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs
by: Liao Jun, et al.
Published: (2023-12-01)

CX3CR1-microglia mediates neuroinflammation and blood pressure regulation in the nucleus tractus solitarii of fructose-induced hypertensive rats
by: Chiu-Yi Ho, et al.
Published: (2020-06-01)

HCC-derived CX3CL1 affects hepatocellular carcinoma prognosis and CX3CR1 + MDSC infiltration
by: Xiaoling Zhang, et al.
Published: (2025-03-01)

Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders
by: Koichi Inoue
Published: (2022-01-01)

Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients
by: Melissa J. Conroy, et al.
Published: (2018-08-01)

Treatment with an Anti-CX3CL1 Antibody Suppresses M1 Macrophage Infiltration in Interstitial Lung Disease in SKG Mice
by: Satoshi Mizutani, et al.
Published: (2021-05-01)

Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1‐CX3CR1 dependent manner and induce tumour cell apoptosis
by: Shuo Miao, et al.
Published: (2020-10-01)

Cochlear resident macrophage mediates development of ribbon synapses via CX3CR1/CX3CL1 axis
by: Xinyu Song, et al.
Published: (2022-11-01)

Effect of CX3CL1/CX3CR1 gene polymorphisms on the clinical efficacy of carboplatin therapy in Han patients with ovarian cancer
by: Xin-Chen Wang, et al.
Published: (2023-01-01)

Overexpression of CX3CR1 in Adipose-Derived Stem Cells Promotes Cell Migration and Functional Recovery After Experimental Intracerebral Hemorrhage
by: Gaigai Li, et al.
Published: (2019-05-01)

CX3CL1 and its receptor CX3CR1 interact with RhoA signaling to induce paclitaxel resistance in gastric cancer
by: Xiangyang Liu, et al.
Published: (2024-04-01)

The CX3CL1-CX3CR1 chemokine axis can contribute to tumor immune evasion and blockade with a novel CX3CR1 monoclonal antibody enhances response to anti-PD-1 immunotherapy
by: Apoorvi Chaudhri, et al.
Published: (2023-09-01)

A double-edged sword: interactions of CX3CL1/CX3CR1 and gut microbiota in systemic lupus erythematosus
by: Rana A. Estaleen, et al.
Published: (2024-01-01)

CX3CL1 release during immunogenic apoptosis is associated with enhanced anti-tumour immunity
by: Faye Naessens, et al.
Published: (2024-07-01)

CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting
by: Xueting Wang, et al.
Published: (2023-05-01)

Computational Insights into the Interaction of the Conserved Cysteine-Noose Domain of the Human Respiratory Syncytial Virus G Protein with the Canonical Fractalkine Binding site of Transmembrane Receptor CX3CR1 Isoforms
by: João Victor Piloto, et al.
Published: (2024-04-01)

Pathophysiological impact of CXC and CX3CL1 chemokines in preeclampsia and gestational diabetes mellitus
by: Amin Ullah, et al.
Published: (2023-10-01)

Neurosteroid [3α,5α]-3-Hydroxy-pregnan-20-one Enhances the CX3CL1-CX3CR1 Pathway in the Brain of Alcohol-Preferring Rats with Sex-Specificity
by: Irina Balan, et al.
Published: (2024-07-01)

CX3CL1-CX3CR1 axis protects retinal ganglion cells by inhibiting microglia activation in a distal optic nerve trauma model
by: Huan Yu, et al.
Published: (2024-06-01)

CX3CL1/Fractalkine: A Potential Biomarker for Liver Fibrosis in Chronic HBV Infection
by: Natalia A. Arsentieva, et al.
Published: (2024-09-01)

The role of сhemokine CX3CL1/Fractalkine in chronic viral hepatitis B
by: Natalia A. Arsentieva, et al.
Published: (2024-07-01)

CX3CR1 mediates neuronal apoptosis by regulating Ca2+ influx to affect the prognosis of ischemic stroke mice
by: LIU Chang, ZHANG Shen, ZHOU Fei-hui, XIA Yang, LI Zhi-gao, WANG Jin-kun, TANG Zhi-wei
Published: (2020-01-01)

Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model
by: Takumi Hasegawa, et al.
Published: (2024-05-01)

The Interplay of Cx26, Cx32, Cx37, Cx40, Cx43, Cx45, and Panx1 in Inner-Ear Development of Yotari (dab1−/−) Mice and Humans
by: Josip Lesko, et al.
Published: (2022-03-01)

Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1–CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice
by: Yang Yang, et al.
Published: (2023-02-01)

Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina
by: Kaira A. Church, et al.
Published: (2023-03-01)

Involvement of CX3CR1+ cells appearing in the abdominal cavity in the immunosuppressive environment immediately after gastric cancer surgery
by: Seiji Natsuki, et al.
Published: (2024-03-01)

An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis
by: Fatemehsadat Pezeshkian, et al.
Published: (2024-10-01)

CX3C chemokine: Hallmarks of fibrosis and ageing
by: Xuanning Chen, et al.
Published: (2024-10-01)

Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis
by: Zi Yang, et al.
Published: (2024-10-01)

CX<sub>3</sub>CL1 (fractalkine) and CX<sub>3</sub>CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin
by: Olsson Tomas, et al.
Published: (2005-07-01)

Expression and significance of Fractalkine/CX3CL1 in MPO-AAV-associated glomerulonephritis rats
by: Junxue Ma, et al.
Published: (2024-06-01)

Exploring CX3CR1 as a prognostic biomarker and immunotherapeutic target in sarcoma
by: Tengfei Li, et al.
Published: (2025-03-01)