Brainstem network dynamics underlying the encoding of bladder information
Urodynamic status must interact with arousal and attentional processes so that voiding occurs under appropriate conditions. To elucidate the central encoding of this visceral demand, multisite recordings were made within a putative pontine-cortical micturition circuit from the pontine micturition ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2017-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/29917 |
| _version_ | 1811200610025865216 |
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| author | Anitha Manohar Andre L Curtis Stephen A Zderic Rita J Valentino |
| author_facet | Anitha Manohar Andre L Curtis Stephen A Zderic Rita J Valentino |
| author_sort | Anitha Manohar |
| collection | DOAJ |
| description | Urodynamic status must interact with arousal and attentional processes so that voiding occurs under appropriate conditions. To elucidate the central encoding of this visceral demand, multisite recordings were made within a putative pontine-cortical micturition circuit from the pontine micturition center (PMC), locus coeruleus (LC) and medial prefrontal cortex (mPFC) during cystometry in unanesthetized rats. PMC neurons had homogeneous firing patterns, characterized by tonic activity and phasic bursts that were temporally associated with distinct phases of the micturition cycle. LC and cortical activation became synchronized 20-30 s prior to micturition. During this pre-micturition interval, a theta oscillation developed in the LC, the mPFC desynchronized and LC-mPFC coherence increased in the theta frequency range. The temporal offset between the shift in LC-mPFC network activity and micturition may allow time to disengage from ongoing behaviors unrelated to micturition and initiate specific voiding behaviors so that micturition occurs in environmentally and socially appropriate conditions. |
| first_indexed | 2024-04-12T02:06:27Z |
| format | Article |
| id | doaj.art-10dc78c1f43f4beaba8cc497e5743eb3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:06:27Z |
| publishDate | 2017-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-10dc78c1f43f4beaba8cc497e5743eb32022-12-22T03:52:31ZengeLife Sciences Publications LtdeLife2050-084X2017-12-01610.7554/eLife.29917Brainstem network dynamics underlying the encoding of bladder informationAnitha Manohar0https://orcid.org/0000-0002-3011-2623Andre L Curtis1Stephen A Zderic2Rita J Valentino3https://orcid.org/0000-0001-6839-6628The Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United StatesThe Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United StatesThe Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United StatesThe Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United StatesUrodynamic status must interact with arousal and attentional processes so that voiding occurs under appropriate conditions. To elucidate the central encoding of this visceral demand, multisite recordings were made within a putative pontine-cortical micturition circuit from the pontine micturition center (PMC), locus coeruleus (LC) and medial prefrontal cortex (mPFC) during cystometry in unanesthetized rats. PMC neurons had homogeneous firing patterns, characterized by tonic activity and phasic bursts that were temporally associated with distinct phases of the micturition cycle. LC and cortical activation became synchronized 20-30 s prior to micturition. During this pre-micturition interval, a theta oscillation developed in the LC, the mPFC desynchronized and LC-mPFC coherence increased in the theta frequency range. The temporal offset between the shift in LC-mPFC network activity and micturition may allow time to disengage from ongoing behaviors unrelated to micturition and initiate specific voiding behaviors so that micturition occurs in environmentally and socially appropriate conditions.https://elifesciences.org/articles/29917bladdermicturitionlocus coeruleusBarrington's nucleuscortexvoiding |
| spellingShingle | Anitha Manohar Andre L Curtis Stephen A Zderic Rita J Valentino Brainstem network dynamics underlying the encoding of bladder information eLife bladder micturition locus coeruleus Barrington's nucleus cortex voiding |
| title | Brainstem network dynamics underlying the encoding of bladder information |
| title_full | Brainstem network dynamics underlying the encoding of bladder information |
| title_fullStr | Brainstem network dynamics underlying the encoding of bladder information |
| title_full_unstemmed | Brainstem network dynamics underlying the encoding of bladder information |
| title_short | Brainstem network dynamics underlying the encoding of bladder information |
| title_sort | brainstem network dynamics underlying the encoding of bladder information |
| topic | bladder micturition locus coeruleus Barrington's nucleus cortex voiding |
| url | https://elifesciences.org/articles/29917 |
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