Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland
Highlights Male and female mouse pituitary gland gene and miRNA expression was profiled across five postnatal ages spanning pubertal development. Sex differences in pituitary gene expression exist prior to puberty and become more prominent upon puberty. Combining expression data from genes and miRNA...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Biology of Sex Differences |
| Online Access: | https://doi.org/10.1186/s13293-022-00467-7 |
| Summary: | Highlights Male and female mouse pituitary gland gene and miRNA expression was profiled across five postnatal ages spanning pubertal development. Sex differences in pituitary gene expression exist prior to puberty and become more prominent upon puberty. Combining expression data from genes and miRNAs revealed 18 putative sex-biased gene targets of 5 sex-biased miRNAs. Sex differences in the proportions of somatotropes, lactotropes, and gonadotropes are predicted to occur prior to puberty. |
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| ISSN: | 2042-6410 |