Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland
Highlights Male and female mouse pituitary gland gene and miRNA expression was profiled across five postnatal ages spanning pubertal development. Sex differences in pituitary gene expression exist prior to puberty and become more prominent upon puberty. Combining expression data from genes and miRNA...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
|
| Series: | Biology of Sex Differences |
| Online Access: | https://doi.org/10.1186/s13293-022-00467-7 |
| _version_ | 1798029959974879232 |
|---|---|
| author | Huayun Hou Cadia Chan Kyoko E. Yuki Dustin Sokolowski Anna Roy Rihao Qu Liis Uusküla-Reimand Mariela Faykoo-Martinez Matt Hudson Christina Corre Anna Goldenberg Zhaolei Zhang Mark R. Palmert Michael D. Wilson |
| author_facet | Huayun Hou Cadia Chan Kyoko E. Yuki Dustin Sokolowski Anna Roy Rihao Qu Liis Uusküla-Reimand Mariela Faykoo-Martinez Matt Hudson Christina Corre Anna Goldenberg Zhaolei Zhang Mark R. Palmert Michael D. Wilson |
| author_sort | Huayun Hou |
| collection | DOAJ |
| description | Highlights Male and female mouse pituitary gland gene and miRNA expression was profiled across five postnatal ages spanning pubertal development. Sex differences in pituitary gene expression exist prior to puberty and become more prominent upon puberty. Combining expression data from genes and miRNAs revealed 18 putative sex-biased gene targets of 5 sex-biased miRNAs. Sex differences in the proportions of somatotropes, lactotropes, and gonadotropes are predicted to occur prior to puberty. |
| first_indexed | 2024-04-11T19:33:44Z |
| format | Article |
| id | doaj.art-10e0feed69a14f379680fda1778efb6d |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-11T19:33:44Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-10e0feed69a14f379680fda1778efb6d2022-12-22T04:06:56ZengBMCBiology of Sex Differences2042-64102022-10-0113112310.1186/s13293-022-00467-7Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary glandHuayun Hou0Cadia Chan1Kyoko E. Yuki2Dustin Sokolowski3Anna Roy4Rihao Qu5Liis Uusküla-Reimand6Mariela Faykoo-Martinez7Matt Hudson8Christina Corre9Anna Goldenberg10Zhaolei Zhang11Mark R. Palmert12Michael D. Wilson13Genetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteInterdepartmental Program of Computational Biology and Bioinformatics, Yale UniversityGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteDepartment of Molecular Genetics, University of TorontoGenetics and Genome Biology, SickKids Research InstituteGenetics and Genome Biology, SickKids Research InstituteHighlights Male and female mouse pituitary gland gene and miRNA expression was profiled across five postnatal ages spanning pubertal development. Sex differences in pituitary gene expression exist prior to puberty and become more prominent upon puberty. Combining expression data from genes and miRNAs revealed 18 putative sex-biased gene targets of 5 sex-biased miRNAs. Sex differences in the proportions of somatotropes, lactotropes, and gonadotropes are predicted to occur prior to puberty.https://doi.org/10.1186/s13293-022-00467-7 |
| spellingShingle | Huayun Hou Cadia Chan Kyoko E. Yuki Dustin Sokolowski Anna Roy Rihao Qu Liis Uusküla-Reimand Mariela Faykoo-Martinez Matt Hudson Christina Corre Anna Goldenberg Zhaolei Zhang Mark R. Palmert Michael D. Wilson Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland Biology of Sex Differences |
| title | Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland |
| title_full | Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland |
| title_fullStr | Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland |
| title_full_unstemmed | Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland |
| title_short | Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland |
| title_sort | postnatal developmental trajectory of sex biased gene expression in the mouse pituitary gland |
| url | https://doi.org/10.1186/s13293-022-00467-7 |
| work_keys_str_mv | AT huayunhou postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT cadiachan postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT kyokoeyuki postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT dustinsokolowski postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT annaroy postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT rihaoqu postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT liisuuskulareimand postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT marielafaykoomartinez postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT matthudson postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT christinacorre postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT annagoldenberg postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT zhaoleizhang postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT markrpalmert postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland AT michaeldwilson postnataldevelopmentaltrajectoryofsexbiasedgeneexpressioninthemousepituitarygland |