Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field
Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/65 |
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| author | Ivan A. Burmistrov Maxim M. Veselov Alexander V. Mikheev Tatiana N. Borodina Tatiana V. Bukreeva Michael A. Chuev Sergey S. Starchikov Igor S. Lyubutin Vladimir V. Artemov Dmitry N. Khmelenin Natalia L. Klyachko Daria B. Trushina |
| author_facet | Ivan A. Burmistrov Maxim M. Veselov Alexander V. Mikheev Tatiana N. Borodina Tatiana V. Bukreeva Michael A. Chuev Sergey S. Starchikov Igor S. Lyubutin Vladimir V. Artemov Dmitry N. Khmelenin Natalia L. Klyachko Daria B. Trushina |
| author_sort | Ivan A. Burmistrov |
| collection | DOAJ |
| description | Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of the encapsulated bioactive substances with high locality and penetration ability without heating of biological tissue in vivo. Therefore, the development of novel microencapsulated drug formulations sensitive to LFMF is of paramount importance. Here, we report the result of LFMF-triggered release of the fluorescently labeled dextran from polyelectrolyte microcapsules modified with magnetic iron oxide nanoparticles. Polyelectrolyte microcapsules were obtained by a method of sequential deposition of oppositely charged poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on the surface of colloidal vaterite particles. The synthesized single domain maghemite nanoparticles integrated into the polymer multilayers serve as magneto-mechanical actuators. We report the first systematic study of the effect of magnetic field with different frequencies on the permeability of the microcapsules. The in situ measurements of the optical density curves upon the 100 mT LFMF treatment were carried out for a range of frequencies from 30 to 150 Hz. Such fields do not cause any considerable heating of the magnetic nanoparticles but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations of the adjacent materials. We observed the changes in release of the encapsulated TRITC-dextran molecules from the PAH/PSS microcapsules upon application of the 50 Hz alternating magnetic field. The obtained results open new horizons for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues. |
| first_indexed | 2024-03-10T00:43:48Z |
| format | Article |
| id | doaj.art-10e2128294c54371ac6db3082c83559c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:43:48Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-10e2128294c54371ac6db3082c83559c2023-11-23T15:03:17ZengMDPI AGPharmaceutics1999-49232021-12-011416510.3390/pharmaceutics14010065Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic FieldIvan A. Burmistrov0Maxim M. Veselov1Alexander V. Mikheev2Tatiana N. Borodina3Tatiana V. Bukreeva4Michael A. Chuev5Sergey S. Starchikov6Igor S. Lyubutin7Vladimir V. Artemov8Dmitry N. Khmelenin9Natalia L. Klyachko10Daria B. Trushina11Shubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaDepartment of Chemical Enzymology, Lomonosov Moscow State University, 119991 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaValiev Institute of Physics and Technology of RAS, 117218 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaDepartment of Chemical Enzymology, Lomonosov Moscow State University, 119991 Moscow, RussiaShubnikov Institute of Crystallography of Federal Scientific Research Centre ‘‘Crystallography and Photonics” of Russian Academy of Sciences, 119333 Moscow, RussiaNanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of the encapsulated bioactive substances with high locality and penetration ability without heating of biological tissue in vivo. Therefore, the development of novel microencapsulated drug formulations sensitive to LFMF is of paramount importance. Here, we report the result of LFMF-triggered release of the fluorescently labeled dextran from polyelectrolyte microcapsules modified with magnetic iron oxide nanoparticles. Polyelectrolyte microcapsules were obtained by a method of sequential deposition of oppositely charged poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on the surface of colloidal vaterite particles. The synthesized single domain maghemite nanoparticles integrated into the polymer multilayers serve as magneto-mechanical actuators. We report the first systematic study of the effect of magnetic field with different frequencies on the permeability of the microcapsules. The in situ measurements of the optical density curves upon the 100 mT LFMF treatment were carried out for a range of frequencies from 30 to 150 Hz. Such fields do not cause any considerable heating of the magnetic nanoparticles but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations of the adjacent materials. We observed the changes in release of the encapsulated TRITC-dextran molecules from the PAH/PSS microcapsules upon application of the 50 Hz alternating magnetic field. The obtained results open new horizons for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.https://www.mdpi.com/1999-4923/14/1/65polyelectrolyte microcapsulestriggered releaseiron oxide nanoparticlesmagnetic actuatorsBrownian relaxation mechanismnon-heating low frequency magnetic field |
| spellingShingle | Ivan A. Burmistrov Maxim M. Veselov Alexander V. Mikheev Tatiana N. Borodina Tatiana V. Bukreeva Michael A. Chuev Sergey S. Starchikov Igor S. Lyubutin Vladimir V. Artemov Dmitry N. Khmelenin Natalia L. Klyachko Daria B. Trushina Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field Pharmaceutics polyelectrolyte microcapsules triggered release iron oxide nanoparticles magnetic actuators Brownian relaxation mechanism non-heating low frequency magnetic field |
| title | Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field |
| title_full | Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field |
| title_fullStr | Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field |
| title_full_unstemmed | Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field |
| title_short | Permeability of the Composite Magnetic Microcapsules Triggered by a Non-Heating Low-Frequency Magnetic Field |
| title_sort | permeability of the composite magnetic microcapsules triggered by a non heating low frequency magnetic field |
| topic | polyelectrolyte microcapsules triggered release iron oxide nanoparticles magnetic actuators Brownian relaxation mechanism non-heating low frequency magnetic field |
| url | https://www.mdpi.com/1999-4923/14/1/65 |
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