Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis

Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis

Summary: Recent evidence demonstrates that colon cancer stem cells (CSCs) can generate neurons that synapse with tumor innervating fibers required for tumorigenesis and disease progression. Greater understanding of the mechanisms that regulate CSC driven tumor neurogenesis may therefore lead to more...

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Bibliographic Details
Main Authors: Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Andreas Steffen, Ralf Lesche, Joern Toedling, Thibaud Jourdan, Johannes Haybaeck, Nicole Golob-Schwarzl, Dominik Mumberg, David Henderson, Balázs Győrffy, Christian R.A. Regenbrecht, Ulrich Keilholz, Reinhold Schäfer, Martin Lange
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:iScience
Subjects:
Stem cells research
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222007696

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http://www.sciencedirect.com/science/article/pii/S2589004222007696

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