Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy
Purpose Metabolic abnormalities in hepatic encephalopathy (HE) cause brain edema or demyelinating disease, resulting in symmetric regional cerebral edema (SRCE) on MRI. This study aimed to investigate the usefulness of the clustering analysis of SRCE in predicting the development of brain failure...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Radiology
2024-03-01
|
| Series: | Journal of the Korean Society of Radiology |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2023.0012 |
| _version_ | 1797236766137122816 |
|---|---|
| author | Chun Geun Lim Hui Joong Lee |
| author_facet | Chun Geun Lim Hui Joong Lee |
| author_sort | Chun Geun Lim |
| collection | DOAJ |
| description | Purpose Metabolic abnormalities in hepatic encephalopathy (HE) cause brain edema or demyelinating
disease, resulting in symmetric regional cerebral edema (SRCE) on MRI. This study
aimed to investigate the usefulness of the clustering analysis of SRCE in predicting the development
of brain failure.
Materials and Methods MR findings and clinical data of 98 consecutive patients with HE were
retrospectively analyzed. The correlation between the 12 regions of SRCE was calculated using
the phi (φ) coefficient, and the pattern was classified using hierarchical clustering using the φ2
distance measure and Ward’s method. The classified patterns of SRCE were correlated with
clinical parameters such as the model for end-stage liver disease (MELD) score and HE grade.
Results Significant associations were found between 22 pairs of regions of interest, including
the red nucleus and corpus callosum (φ = 0.81, p < 0.001), crus cerebri and red nucleus (φ =
0.72, p < 0.001), and red nucleus and dentate nucleus (φ = 0.66, p < 0.001). After hierarchical
clustering, 24 cases were classified into Group I, 35 into Group II, and 39 into Group III. Group III
had a higher MELD score (p = 0.04) and HE grade (p = 0.002) than Group I.
Conclusion Our study demonstrates that the SRCE patterns can be useful in predicting hepatic
preservation and the occurrence of cerebral failure in HE. |
| first_indexed | 2024-04-24T17:09:04Z |
| format | Article |
| id | doaj.art-10e459a4865041d6a2f19ff13d70de34 |
| institution | Directory Open Access Journal |
| issn | 2951-0805 |
| language | English |
| last_indexed | 2024-04-24T17:09:04Z |
| publishDate | 2024-03-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | Journal of the Korean Society of Radiology |
| spelling | doaj.art-10e459a4865041d6a2f19ff13d70de342024-03-28T13:42:56ZengThe Korean Society of RadiologyJournal of the Korean Society of Radiology2951-08052024-03-01852381393https://doi.org/10.3348/jksr.2023.0012Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic EncephalopathyChun Geun LimHui Joong LeePurpose Metabolic abnormalities in hepatic encephalopathy (HE) cause brain edema or demyelinating disease, resulting in symmetric regional cerebral edema (SRCE) on MRI. This study aimed to investigate the usefulness of the clustering analysis of SRCE in predicting the development of brain failure. Materials and Methods MR findings and clinical data of 98 consecutive patients with HE were retrospectively analyzed. The correlation between the 12 regions of SRCE was calculated using the phi (φ) coefficient, and the pattern was classified using hierarchical clustering using the φ2 distance measure and Ward’s method. The classified patterns of SRCE were correlated with clinical parameters such as the model for end-stage liver disease (MELD) score and HE grade. Results Significant associations were found between 22 pairs of regions of interest, including the red nucleus and corpus callosum (φ = 0.81, p < 0.001), crus cerebri and red nucleus (φ = 0.72, p < 0.001), and red nucleus and dentate nucleus (φ = 0.66, p < 0.001). After hierarchical clustering, 24 cases were classified into Group I, 35 into Group II, and 39 into Group III. Group III had a higher MELD score (p = 0.04) and HE grade (p = 0.002) than Group I. Conclusion Our study demonstrates that the SRCE patterns can be useful in predicting hepatic preservation and the occurrence of cerebral failure in HE.https://doi.org/10.3348/jksr.2023.0012hepatic encephalopathycerebral edemamagnetic resonance image |
| spellingShingle | Chun Geun Lim Hui Joong Lee Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy Journal of the Korean Society of Radiology hepatic encephalopathy cerebral edema magnetic resonance image |
| title | Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy |
| title_full | Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy |
| title_fullStr | Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy |
| title_full_unstemmed | Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy |
| title_short | Pattern Clustering of Symmetric Regional Cerebral Edema on Brain MRI in Patients with Hepatic Encephalopathy |
| title_sort | pattern clustering of symmetric regional cerebral edema on brain mri in patients with hepatic encephalopathy |
| topic | hepatic encephalopathy cerebral edema magnetic resonance image |
| url | https://doi.org/10.3348/jksr.2023.0012 |
| work_keys_str_mv | AT chungeunlim patternclusteringofsymmetricregionalcerebraledemaonbrainmriinpatientswithhepaticencephalopathy AT huijoonglee patternclusteringofsymmetricregionalcerebraledemaonbrainmriinpatientswithhepaticencephalopathy |