Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection
Among women, breast cancer (BC) is not only the most common cancer worldwide but also the leading cause of cancer death. Only 5–10% of breast cancer cases are attributed to inherited mutations (BRCA1, BRCA2, and other breast cancer susceptibility genes). Breast cancer incidence has been rising parti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2020.00028/full |
| _version_ | 1811278094675214336 |
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| author | Farah J. Nassar Ghada Chamandi Mohamad Ali Tfaily Nathalie Khoueiry Zgheib Rihab Nasr |
| author_facet | Farah J. Nassar Ghada Chamandi Mohamad Ali Tfaily Nathalie Khoueiry Zgheib Rihab Nasr |
| author_sort | Farah J. Nassar |
| collection | DOAJ |
| description | Among women, breast cancer (BC) is not only the most common cancer worldwide but also the leading cause of cancer death. Only 5–10% of breast cancer cases are attributed to inherited mutations (BRCA1, BRCA2, and other breast cancer susceptibility genes). Breast cancer incidence has been rising particularly in young women who are not eligible for mammography, and it has been acting as a burden especially in developing countries that lack screening and awareness programs. For this reason, research has shifted to use minimally invasive liquid biopsies especially blood-based biomarkers with potential value for breast cancer risk prediction and early detection. This mini-review will tackle the different blood-based biomarkers focusing mainly on circulating miRNA, circulating proteins, cell-free nucleic acids, methylation patterns, and exosomes. It also introduces the potential opportunities for the clinical use of these blood-based biomarkers for breast cancer risk prediction. |
| first_indexed | 2024-04-13T00:29:41Z |
| format | Article |
| id | doaj.art-10e4a09f6f0841c29978460404a1ce48 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T00:29:41Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-10e4a09f6f0841c29978460404a1ce482022-12-22T03:10:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-02-01710.3389/fmed.2020.00028464288Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early DetectionFarah J. Nassar0Ghada Chamandi1Mohamad Ali Tfaily2Nathalie Khoueiry Zgheib3Rihab Nasr4Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, LebanonAmong women, breast cancer (BC) is not only the most common cancer worldwide but also the leading cause of cancer death. Only 5–10% of breast cancer cases are attributed to inherited mutations (BRCA1, BRCA2, and other breast cancer susceptibility genes). Breast cancer incidence has been rising particularly in young women who are not eligible for mammography, and it has been acting as a burden especially in developing countries that lack screening and awareness programs. For this reason, research has shifted to use minimally invasive liquid biopsies especially blood-based biomarkers with potential value for breast cancer risk prediction and early detection. This mini-review will tackle the different blood-based biomarkers focusing mainly on circulating miRNA, circulating proteins, cell-free nucleic acids, methylation patterns, and exosomes. It also introduces the potential opportunities for the clinical use of these blood-based biomarkers for breast cancer risk prediction.https://www.frontiersin.org/article/10.3389/fmed.2020.00028/fullbreast cancerliquid biopsyearly detectionrisk predictionmicroRNAcfDNA |
| spellingShingle | Farah J. Nassar Ghada Chamandi Mohamad Ali Tfaily Nathalie Khoueiry Zgheib Rihab Nasr Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection Frontiers in Medicine breast cancer liquid biopsy early detection risk prediction microRNA cfDNA |
| title | Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection |
| title_full | Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection |
| title_fullStr | Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection |
| title_full_unstemmed | Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection |
| title_short | Peripheral Blood-Based Biopsy for Breast Cancer Risk Prediction and Early Detection |
| title_sort | peripheral blood based biopsy for breast cancer risk prediction and early detection |
| topic | breast cancer liquid biopsy early detection risk prediction microRNA cfDNA |
| url | https://www.frontiersin.org/article/10.3389/fmed.2020.00028/full |
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