Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response

Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response

Abstract Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family may have off-target effects genome-wide, but its effects at pan-cancer level are not well e...

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Main Authors: Isaias Hernández-Verdin, Kadir C. Akdemir, Daniele Ramazzotti, Giulio Caravagna, Karim Labreche, Karima Mokhtari, Khê Hoang-Xuan, Matthieu Peyre, Franck Bielle, Mehdi Touat, Ahmed Idbaih, Alex Duval, Marc Sanson, Agustí Alentorn
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00331-2

Internet

https://doi.org/10.1038/s41698-022-00331-2

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