Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration
Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events. The aim of this paper was to examine the associations of blood glucose level (BGL), glycated hemoglobin (HbA1c) and duration of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00130/full |
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| author | Mika P. Tarvainen Mika P. Tarvainen Tomi Petteri Laitinen Jukka Antero Lipponen David eCornforth Herbert eJelinek |
| author_facet | Mika P. Tarvainen Mika P. Tarvainen Tomi Petteri Laitinen Jukka Antero Lipponen David eCornforth Herbert eJelinek |
| author_sort | Mika P. Tarvainen |
| collection | DOAJ |
| description | Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events. The aim of this paper was to examine the associations of blood glucose level (BGL), glycated hemoglobin (HbA1c) and duration of diabetes with cardiac autonomic regulation assessed by HRV analysis. Resting electrocardiogram (ECG), recorded over 20 minutes in supine position, and clinical measurements of 189 healthy controls and 93 type 2 DM (T2DM) patients were analyzed. HRV was assessed using several time-domain, frequency-domain and nonlinear methods. HRV parameters showed a clear difference between healthy controls and T2DM patients. Hyperglycemia was associated with increase in mean heart rate and decrease in HRV, indicated by negative correlations of BGL and HbA1c with mean RR interval and most of the HRV parameters. Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease. In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients. The most significant decrease in HRV related to diabetes and thus presence of autonomic neuropathy was observed within the first 5-10 years of disease progression. |
| first_indexed | 2024-12-12T03:02:12Z |
| format | Article |
| id | doaj.art-10e7f338c4a5436b8b1817e0611ac89e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T03:02:12Z |
| publishDate | 2014-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-10e7f338c4a5436b8b1817e0611ac89e2022-12-22T00:40:36ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-08-01510.3389/fendo.2014.00130105534Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease DurationMika P. Tarvainen0Mika P. Tarvainen1Tomi Petteri Laitinen2Jukka Antero Lipponen3David eCornforth4Herbert eJelinek5University of Eastern FinlandKuopio University HospitalUniversity of Eastern Finland and Kuopio University HospitalUniversity of Eastern FinlandUniversity of NewcastleCharles Sturt University, AlburyHeart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation and an increased risk for cardiac events. The aim of this paper was to examine the associations of blood glucose level (BGL), glycated hemoglobin (HbA1c) and duration of diabetes with cardiac autonomic regulation assessed by HRV analysis. Resting electrocardiogram (ECG), recorded over 20 minutes in supine position, and clinical measurements of 189 healthy controls and 93 type 2 DM (T2DM) patients were analyzed. HRV was assessed using several time-domain, frequency-domain and nonlinear methods. HRV parameters showed a clear difference between healthy controls and T2DM patients. Hyperglycemia was associated with increase in mean heart rate and decrease in HRV, indicated by negative correlations of BGL and HbA1c with mean RR interval and most of the HRV parameters. Duration of diabetes was strongly associated with decrease in HRV, the most significant decrease in HRV was found within the first 5-10 years of the disease. In conclusion, elevated blood glucose levels have an unfavorable effect on cardiac autonomic function and this effect is pronounced in long-term T2DM patients. The most significant decrease in HRV related to diabetes and thus presence of autonomic neuropathy was observed within the first 5-10 years of disease progression.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00130/fullBlood GlucoseHyperglycemiaHeart rate variabilitydurationHbA1ccardiac autonomic neuropathy |
| spellingShingle | Mika P. Tarvainen Mika P. Tarvainen Tomi Petteri Laitinen Jukka Antero Lipponen David eCornforth Herbert eJelinek Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration Frontiers in Endocrinology Blood Glucose Hyperglycemia Heart rate variability duration HbA1c cardiac autonomic neuropathy |
| title | Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration |
| title_full | Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration |
| title_fullStr | Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration |
| title_full_unstemmed | Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration |
| title_short | Cardiac Autonomic Dysfunction in Type 2 Diabetes – Effect of Hyperglycemia and Disease Duration |
| title_sort | cardiac autonomic dysfunction in type 2 diabetes effect of hyperglycemia and disease duration |
| topic | Blood Glucose Hyperglycemia Heart rate variability duration HbA1c cardiac autonomic neuropathy |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00130/full |
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