Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females
Context: Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. Aim: The aim of this work was to determine hormonal levels and lipid profil...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=5;spage=9;epage=16;aulast=Bakry |
| _version_ | 1818427951550562304 |
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| author | Ola Ahmed Bakry Rania Mohamed Azmy El Shazly Shawky Mahmoud El Farargy Dalia Kotb |
| author_facet | Ola Ahmed Bakry Rania Mohamed Azmy El Shazly Shawky Mahmoud El Farargy Dalia Kotb |
| author_sort | Ola Ahmed Bakry |
| collection | DOAJ |
| description | Context: Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. Aim: The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV. Subjects and Methods: A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG), estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle. Results: Total testosterone, free testosterone (FT) and progesterone levels were significantly higher (P < 0.001 for all) while estradiol levels (P < 0.001) and SHBG (P < 0.01) were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C) levels were significantly higher (P < 0.001 for both) while high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA-1) levels were significantly lower (P < 0.001 for both) in cases than controls. Higher values of FT (P = 0.03) and SHBG (P = 0.02) and lower values of estradiol (P = 0.04) levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001) and LDL-C (P = 0.03) and lower values of HDL-C (P = 0.01) and ApoA-1 (P = 0.02) levels were significantly associated with severe acne. Conclusion: Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients. |
| first_indexed | 2024-12-14T14:53:53Z |
| format | Article |
| id | doaj.art-10ea927b0df6453ea1c42810732392c4 |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-14T14:53:53Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-10ea927b0df6453ea1c42810732392c42022-12-21T22:57:02ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782014-01-015591610.4103/2229-5178.144506Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute femalesOla Ahmed BakryRania Mohamed Azmy El ShazlyShawky Mahmoud El FarargyDalia KotbContext: Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. Aim: The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV. Subjects and Methods: A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG), estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle. Results: Total testosterone, free testosterone (FT) and progesterone levels were significantly higher (P < 0.001 for all) while estradiol levels (P < 0.001) and SHBG (P < 0.01) were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C) levels were significantly higher (P < 0.001 for both) while high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA-1) levels were significantly lower (P < 0.001 for both) in cases than controls. Higher values of FT (P = 0.03) and SHBG (P = 0.02) and lower values of estradiol (P = 0.04) levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001) and LDL-C (P = 0.03) and lower values of HDL-C (P = 0.01) and ApoA-1 (P = 0.02) levels were significantly associated with severe acne. Conclusion: Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients.http://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=5;spage=9;epage=16;aulast=BakryAcne vulgarisfemalehormoneslipid profile |
| spellingShingle | Ola Ahmed Bakry Rania Mohamed Azmy El Shazly Shawky Mahmoud El Farargy Dalia Kotb Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females Indian Dermatology Online Journal Acne vulgaris female hormones lipid profile |
| title | Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females |
| title_full | Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females |
| title_fullStr | Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females |
| title_full_unstemmed | Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females |
| title_short | Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females |
| title_sort | role of hormones and blood lipids in the pathogenesis of acne vulgaris in non obese non hirsute females |
| topic | Acne vulgaris female hormones lipid profile |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=5;spage=9;epage=16;aulast=Bakry |
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