Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus
AimThe objective was to investigate the association of periodontitis and tooth loss with extent of diabetic coronary atherosclerosis.Materials and methods272 patients who were hospitalized at Shanghai East hospital and underwent a coronary artery calcium (CAC) CT scan were enrolled in this study. In...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1243992/full |
| _version_ | 1797498442267754496 |
|---|---|
| author | Minhua Shen Zhen Li Huizhi Li Xinfeng Yan Bo Feng Lei Xu |
| author_facet | Minhua Shen Zhen Li Huizhi Li Xinfeng Yan Bo Feng Lei Xu |
| author_sort | Minhua Shen |
| collection | DOAJ |
| description | AimThe objective was to investigate the association of periodontitis and tooth loss with extent of diabetic coronary atherosclerosis.Materials and methods272 patients who were hospitalized at Shanghai East hospital and underwent a coronary artery calcium (CAC) CT scan were enrolled in this study. Individuals were grouped based on their CAC scores into a normal-to-mild coronary atherosclerosis (AS) group (0 ≤ score ≤ 100, n=184) and a moderate-to-severe group (score≥101, n=88). Periodontitis parameters and number of missing teeth were evaluated for every patient. The severity of periodontitis was categorized as mild, moderate, or severe. The taxonomic composition of the microbiota was determined using full-length 16S ribosomal RNA gene sequencing. Salivary inflammatory factors were tested by ELISA.ResultsClinical attachment loss (CAL) (P =0.05) and the number of teeth lost (P = 0.016) were significantly higher in the moderate-to-severe coronary AS group, with these differences being more obvious in younger patients and patients with short-duration diabetes. Multivariate logistic regression analysis revealed that CAL (OR = 1.231, 95% CI = 1.066–1.214, P = 0.047) and having 10–19 missing teeth (OR = 1.604, 95% CI = 1.393–6.555, P = 0.05) were strongly associated with the presence of moderate-to-severe coronary AS. Salivary IL-6 and TNF-α levels, as well as levels of Porphyromonas gingivalis and Neisseria mucosa, were significantly elevated in the moderate-to-severe coronary AS group.ConclusionIt was found that both tooth loss and CAL were related to the extent of diabetic coronary AS. Saliva inflammatory factors and oral bacteremia may be new biomarkers for moderate-to-severe coronary AS. |
| first_indexed | 2024-03-10T03:33:26Z |
| format | Article |
| id | doaj.art-10ebe2a11cfc45878cc49e0526a7fba2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-10T03:33:26Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-10ebe2a11cfc45878cc49e0526a7fba22023-11-23T11:50:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-11-011410.3389/fendo.2023.12439921243992Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitusMinhua Shen0Zhen Li1Huizhi Li2Xinfeng Yan3Bo Feng4Lei Xu5Department of Stomatology, East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Stomatology, East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, ChinaAimThe objective was to investigate the association of periodontitis and tooth loss with extent of diabetic coronary atherosclerosis.Materials and methods272 patients who were hospitalized at Shanghai East hospital and underwent a coronary artery calcium (CAC) CT scan were enrolled in this study. Individuals were grouped based on their CAC scores into a normal-to-mild coronary atherosclerosis (AS) group (0 ≤ score ≤ 100, n=184) and a moderate-to-severe group (score≥101, n=88). Periodontitis parameters and number of missing teeth were evaluated for every patient. The severity of periodontitis was categorized as mild, moderate, or severe. The taxonomic composition of the microbiota was determined using full-length 16S ribosomal RNA gene sequencing. Salivary inflammatory factors were tested by ELISA.ResultsClinical attachment loss (CAL) (P =0.05) and the number of teeth lost (P = 0.016) were significantly higher in the moderate-to-severe coronary AS group, with these differences being more obvious in younger patients and patients with short-duration diabetes. Multivariate logistic regression analysis revealed that CAL (OR = 1.231, 95% CI = 1.066–1.214, P = 0.047) and having 10–19 missing teeth (OR = 1.604, 95% CI = 1.393–6.555, P = 0.05) were strongly associated with the presence of moderate-to-severe coronary AS. Salivary IL-6 and TNF-α levels, as well as levels of Porphyromonas gingivalis and Neisseria mucosa, were significantly elevated in the moderate-to-severe coronary AS group.ConclusionIt was found that both tooth loss and CAL were related to the extent of diabetic coronary AS. Saliva inflammatory factors and oral bacteremia may be new biomarkers for moderate-to-severe coronary AS.https://www.frontiersin.org/articles/10.3389/fendo.2023.1243992/fullperiodontitistooth lossdiabetescoronary atherosclerosisCAC scores |
| spellingShingle | Minhua Shen Zhen Li Huizhi Li Xinfeng Yan Bo Feng Lei Xu Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus Frontiers in Endocrinology periodontitis tooth loss diabetes coronary atherosclerosis CAC scores |
| title | Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus |
| title_full | Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus |
| title_fullStr | Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus |
| title_short | Association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus |
| title_sort | association of periodontitis and tooth loss with extent of coronary atherosclerosis in patients with type 2 diabetes mellitus |
| topic | periodontitis tooth loss diabetes coronary atherosclerosis CAC scores |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1243992/full |
| work_keys_str_mv | AT minhuashen associationofperiodontitisandtoothlosswithextentofcoronaryatherosclerosisinpatientswithtype2diabetesmellitus AT zhenli associationofperiodontitisandtoothlosswithextentofcoronaryatherosclerosisinpatientswithtype2diabetesmellitus AT huizhili associationofperiodontitisandtoothlosswithextentofcoronaryatherosclerosisinpatientswithtype2diabetesmellitus AT xinfengyan associationofperiodontitisandtoothlosswithextentofcoronaryatherosclerosisinpatientswithtype2diabetesmellitus AT bofeng associationofperiodontitisandtoothlosswithextentofcoronaryatherosclerosisinpatientswithtype2diabetesmellitus AT leixu associationofperiodontitisandtoothlosswithextentofcoronaryatherosclerosisinpatientswithtype2diabetesmellitus |