Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique
OBJECTIVE Recent data from the literature have recognized the importance of cerebellum in bipolar disorder. Brain imaging studies focusing on cerebellar volumetric changes in bipolar disorder demonstrated controversial data. The aim of this study is to investigate whether there is any difference bet...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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AVES
2019-07-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24750573.2019.1637040 |
| _version_ | 1828020034311553024 |
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| author | Burcu Serim Demirgören Aylin Özbek Nüket Göçmen Karabekir Bari Ay Serkan Turan Gökşin Nilüfer Yonguç Selim Karabekir Ayşe İpek Polat Ayşe Semra Hız Özlem Gencer Kıdak |
| author_facet | Burcu Serim Demirgören Aylin Özbek Nüket Göçmen Karabekir Bari Ay Serkan Turan Gökşin Nilüfer Yonguç Selim Karabekir Ayşe İpek Polat Ayşe Semra Hız Özlem Gencer Kıdak |
| author_sort | Burcu Serim Demirgören |
| collection | DOAJ |
| description | OBJECTIVE Recent data from the literature have recognized the importance of cerebellum in bipolar disorder. Brain imaging studies focusing on cerebellar volumetric changes in bipolar disorder demonstrated controversial data. The aim of this study is to investigate whether there is any difference between early-onset bipolar cases and healthy controls regarding cerebellar volumetric measurements. METHODS Patients with bipolar I disorder were compared to healthy controls in terms of total cerebellar volume, volumes of the right and left cerebellar hemispheres, and cerebellar volumetric asymmetry. All the sociodemographic, clinical data, and magnetic resonance image scans were collected retrospectively. Cerebellar volumes were evaluated using the stereological method. Asymmetry indices were calculated subsequently. RESULTS We recruited 10 bipolar I cases and 10 healthy controls. There were no statistically significant differences between the bipolar and the control groups for total cerebellar volumes, volumes of right and left cerebellar hemispheres, and cerebellar asymmetry indices. CONCLUSION Future studies focusing on cerebellar changes in early-onset bipolar disorder should include large case and control series and designed as follow-up studies for being able to determine the chronic effects of the illness on cerebellar volumes. |
| first_indexed | 2024-04-10T11:30:33Z |
| format | Article |
| id | doaj.art-10ec616caff44d69b78d654e2f4883cb |
| institution | Directory Open Access Journal |
| issn | 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T11:30:33Z |
| publishDate | 2019-07-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-10ec616caff44d69b78d654e2f4883cb2023-02-15T16:18:07ZengAVESPsychiatry and Clinical Psychopharmacology2475-05812019-07-0129329329710.1080/24750573.2019.16370401637040Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement techniqueBurcu Serim Demirgören0Aylin Özbek1Nüket Göçmen Karabekir2Bari Ay3Serkan Turan4Gökşin Nilüfer Yonguç5Selim Karabekir6Ayşe İpek Polat7Ayşe Semra Hız8Özlem Gencer Kıdak9Dokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityDokuz Eylul UniversityOBJECTIVE Recent data from the literature have recognized the importance of cerebellum in bipolar disorder. Brain imaging studies focusing on cerebellar volumetric changes in bipolar disorder demonstrated controversial data. The aim of this study is to investigate whether there is any difference between early-onset bipolar cases and healthy controls regarding cerebellar volumetric measurements. METHODS Patients with bipolar I disorder were compared to healthy controls in terms of total cerebellar volume, volumes of the right and left cerebellar hemispheres, and cerebellar volumetric asymmetry. All the sociodemographic, clinical data, and magnetic resonance image scans were collected retrospectively. Cerebellar volumes were evaluated using the stereological method. Asymmetry indices were calculated subsequently. RESULTS We recruited 10 bipolar I cases and 10 healthy controls. There were no statistically significant differences between the bipolar and the control groups for total cerebellar volumes, volumes of right and left cerebellar hemispheres, and cerebellar asymmetry indices. CONCLUSION Future studies focusing on cerebellar changes in early-onset bipolar disorder should include large case and control series and designed as follow-up studies for being able to determine the chronic effects of the illness on cerebellar volumes.http://dx.doi.org/10.1080/24750573.2019.1637040early-onset bipolar disordercerebellumstereologymagnetic resonance imagingvolumetric measurementscerebellar asymmetry |
| spellingShingle | Burcu Serim Demirgören Aylin Özbek Nüket Göçmen Karabekir Bari Ay Serkan Turan Gökşin Nilüfer Yonguç Selim Karabekir Ayşe İpek Polat Ayşe Semra Hız Özlem Gencer Kıdak Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique Psychiatry and Clinical Psychopharmacology early-onset bipolar disorder cerebellum stereology magnetic resonance imaging volumetric measurements cerebellar asymmetry |
| title | Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique |
| title_full | Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique |
| title_fullStr | Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique |
| title_full_unstemmed | Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique |
| title_short | Cerebellar volumes in early-onset bipolar disorder: a pilot study of a stereological measurement technique |
| title_sort | cerebellar volumes in early onset bipolar disorder a pilot study of a stereological measurement technique |
| topic | early-onset bipolar disorder cerebellum stereology magnetic resonance imaging volumetric measurements cerebellar asymmetry |
| url | http://dx.doi.org/10.1080/24750573.2019.1637040 |
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