Current trends and challenges in cancer management and therapy using designer nanomaterials
Abstract Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-07-01
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| Series: | Nano Convergence |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40580-019-0193-2 |
| _version_ | 1819093494789046272 |
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| author | P. N. Navya Anubhav Kaphle S. P. Srinivas Suresh Kumar Bhargava Vincent M. Rotello Hemant Kumar Daima |
| author_facet | P. N. Navya Anubhav Kaphle S. P. Srinivas Suresh Kumar Bhargava Vincent M. Rotello Hemant Kumar Daima |
| author_sort | P. N. Navya |
| collection | DOAJ |
| description | Abstract Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. Therefore, in this critical review, we summarize a range of nanomaterials which are currently being employed for anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We further elaborate on the topical progress made to date toward nanomaterial engineering for cancer therapy, including current strategies for drug targeting and release for efficient cancer administration. We also discuss issues of nanotoxicity, which is an often-neglected feature of nanotechnology. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field. |
| first_indexed | 2024-12-21T23:12:25Z |
| format | Article |
| id | doaj.art-10ecdf9068804198b775ff9429a3263e |
| institution | Directory Open Access Journal |
| issn | 2196-5404 |
| language | English |
| last_indexed | 2024-12-21T23:12:25Z |
| publishDate | 2019-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nano Convergence |
| spelling | doaj.art-10ecdf9068804198b775ff9429a3263e2022-12-21T18:47:00ZengSpringerOpenNano Convergence2196-54042019-07-016113010.1186/s40580-019-0193-2Current trends and challenges in cancer management and therapy using designer nanomaterialsP. N. Navya0Anubhav Kaphle1S. P. Srinivas2Suresh Kumar Bhargava3Vincent M. Rotello4Hemant Kumar Daima5Nano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of TechnologyMelbourne Integrative Genomics, School of BioSciences/School of Mathematics and Statistics, The University of MelbourneSchool of Optometry, Indiana UniversityCentre for Advanced Materials and Industrial Chemistry, School of Science, RMIT UniversityDepartment of Chemistry, University of Massachusetts (UMass) AmherstNano-Bio Interfacial Research Laboratory (NBIRL), Department of Biotechnology, Siddaganga Institute of TechnologyAbstract Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. Therefore, in this critical review, we summarize a range of nanomaterials which are currently being employed for anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We further elaborate on the topical progress made to date toward nanomaterial engineering for cancer therapy, including current strategies for drug targeting and release for efficient cancer administration. We also discuss issues of nanotoxicity, which is an often-neglected feature of nanotechnology. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field.http://link.springer.com/article/10.1186/s40580-019-0193-2Drug deliveryCancer therapyEngineered nanomaterialsNext-generationNanotoxicity |
| spellingShingle | P. N. Navya Anubhav Kaphle S. P. Srinivas Suresh Kumar Bhargava Vincent M. Rotello Hemant Kumar Daima Current trends and challenges in cancer management and therapy using designer nanomaterials Nano Convergence Drug delivery Cancer therapy Engineered nanomaterials Next-generation Nanotoxicity |
| title | Current trends and challenges in cancer management and therapy using designer nanomaterials |
| title_full | Current trends and challenges in cancer management and therapy using designer nanomaterials |
| title_fullStr | Current trends and challenges in cancer management and therapy using designer nanomaterials |
| title_full_unstemmed | Current trends and challenges in cancer management and therapy using designer nanomaterials |
| title_short | Current trends and challenges in cancer management and therapy using designer nanomaterials |
| title_sort | current trends and challenges in cancer management and therapy using designer nanomaterials |
| topic | Drug delivery Cancer therapy Engineered nanomaterials Next-generation Nanotoxicity |
| url | http://link.springer.com/article/10.1186/s40580-019-0193-2 |
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