Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury
Traumatic central nervous system injury, including traumatic brain injury and spinal cord injury, has extremely high disability and mortality rates. The huge medical expenses and sequelae further aggravate the economic and psychological burden of patients and their families. Current treatments for t...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2024-04-01
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| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/20230509.pdf |
| _version_ | 1797216476848979968 |
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| author | YANG Yiran, WANG Chun, DENG Sangyang, JIANG Chen, WU Haiying, QIAN Chuanyun |
| author_facet | YANG Yiran, WANG Chun, DENG Sangyang, JIANG Chen, WU Haiying, QIAN Chuanyun |
| author_sort | YANG Yiran, WANG Chun, DENG Sangyang, JIANG Chen, WU Haiying, QIAN Chuanyun |
| collection | DOAJ |
| description | Traumatic central nervous system injury, including traumatic brain injury and spinal cord injury, has extremely high disability and mortality rates. The huge medical expenses and sequelae further aggravate the economic and psychological burden of patients and their families. Current treatments for traumatic central nervous system injury include surgical therapy, physical therapy, medication and post-rehabilitation treatment, but none of them can achieve ideal efficacy, and more effective treatment is urgently needed. Ferroptosis, as one of the newly discovered modes of programmed cell death, has been shown to play a crucial role in secondary injury to the traumatic central nervous system, but its clinical transformation is limited. This article summarizes the research results of ferroptosis inhibitors, points out the types and effects of them, to provide new ideas for clinical treatment of traumatic central nervous system injury and drug development. |
| first_indexed | 2024-04-24T11:46:34Z |
| format | Article |
| id | doaj.art-10ed7868ba904c519efda148a3022580 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:46:34Z |
| publishDate | 2024-04-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-10ed7868ba904c519efda148a30225802024-04-09T09:20:46ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722024-04-0127111395139910.12114/j.issn.1007-9572.2023.0509Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System InjuryYANG Yiran, WANG Chun, DENG Sangyang, JIANG Chen, WU Haiying, QIAN Chuanyun0Emergency Medicine Department, First Affiliated Hospital of Kunming Medical University, Kunming 650000, ChinaTraumatic central nervous system injury, including traumatic brain injury and spinal cord injury, has extremely high disability and mortality rates. The huge medical expenses and sequelae further aggravate the economic and psychological burden of patients and their families. Current treatments for traumatic central nervous system injury include surgical therapy, physical therapy, medication and post-rehabilitation treatment, but none of them can achieve ideal efficacy, and more effective treatment is urgently needed. Ferroptosis, as one of the newly discovered modes of programmed cell death, has been shown to play a crucial role in secondary injury to the traumatic central nervous system, but its clinical transformation is limited. This article summarizes the research results of ferroptosis inhibitors, points out the types and effects of them, to provide new ideas for clinical treatment of traumatic central nervous system injury and drug development.https://www.chinagp.net/fileup/1007-9572/PDF/20230509.pdftraumatic central nervous system injury|traumatic brain injury|spinal cord injury|ferroptosis|therapy |
| spellingShingle | YANG Yiran, WANG Chun, DENG Sangyang, JIANG Chen, WU Haiying, QIAN Chuanyun Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury Zhongguo quanke yixue traumatic central nervous system injury|traumatic brain injury|spinal cord injury|ferroptosis|therapy |
| title | Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury |
| title_full | Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury |
| title_fullStr | Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury |
| title_full_unstemmed | Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury |
| title_short | Advances in Ferroptosis in the Treatment of Traumatic Central Nervous System Injury |
| title_sort | advances in ferroptosis in the treatment of traumatic central nervous system injury |
| topic | traumatic central nervous system injury|traumatic brain injury|spinal cord injury|ferroptosis|therapy |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/20230509.pdf |
| work_keys_str_mv | AT yangyiranwangchundengsangyangjiangchenwuhaiyingqianchuanyun advancesinferroptosisinthetreatmentoftraumaticcentralnervoussysteminjury |