Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo
In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2015-01-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545815400039 |
| _version_ | 1811256003427041280 |
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| author | Li-Jun Zhang Lai-Xing Wang Wei-Li Zhang Yi-Jia Yan Zhi-Long Chen |
| author_facet | Li-Jun Zhang Lai-Xing Wang Wei-Li Zhang Yi-Jia Yan Zhi-Long Chen |
| author_sort | Li-Jun Zhang |
| collection | DOAJ |
| description | In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50 mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation. |
| first_indexed | 2024-04-12T17:33:34Z |
| format | Article |
| id | doaj.art-10edcfe263f14a99986a2f6b1a08bb85 |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-04-12T17:33:34Z |
| publishDate | 2015-01-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-10edcfe263f14a99986a2f6b1a08bb852022-12-22T03:23:04ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052015-01-01811540003-11540003-1110.1142/S179354581540003910.1142/S1793545815400039Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivoLi-Jun Zhang0Lai-Xing Wang1Wei-Li Zhang2Yi-Jia Yan3Zhi-Long Chen4Department of Pharmaceutical Science & Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, P. R. ChinaChanghai Hospital, Second Military Medical University, Shanghai 200433, P. R. ChinaDepartment of Pharmaceutical Science & Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, P. R. ChinaDepartment of Pharmaceutical Science & Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, P. R. ChinaDepartment of Pharmaceutical Science & Technology, College of Chemistry and Biology, Donghua University, Shanghai 201620, P. R. ChinaIn this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50 mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation.http://www.worldscientific.com/doi/pdf/10.1142/S1793545815400039TPMCchlorintumorphotosensitizerphotodynamic therapy |
| spellingShingle | Li-Jun Zhang Lai-Xing Wang Wei-Li Zhang Yi-Jia Yan Zhi-Long Chen Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo Journal of Innovative Optical Health Sciences TPMC chlorin tumor photosensitizer photodynamic therapy |
| title | Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
| title_full | Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
| title_fullStr | Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
| title_full_unstemmed | Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
| title_short | Anti-tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
| title_sort | anti tumor activities of a novel chlorin derivative for photodynamic therapy in vitro and in vivo |
| topic | TPMC chlorin tumor photosensitizer photodynamic therapy |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545815400039 |
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