Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder
Background: Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as docume...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-02-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2018.00051/full |
| _version_ | 1818243945727000576 |
|---|---|
| author | Keren Bachi Muhammad A. Parvaz Scott J. Moeller Scott J. Moeller Gabriela Gan Gabriela Gan Anna Zilverstand Rita Z. Goldstein Nelly Alia-Klein |
| author_facet | Keren Bachi Muhammad A. Parvaz Scott J. Moeller Scott J. Moeller Gabriela Gan Gabriela Gan Anna Zilverstand Rita Z. Goldstein Nelly Alia-Klein |
| author_sort | Keren Bachi |
| collection | DOAJ |
| description | Background: Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as documented separately in addiction and for childhood trauma. The purpose of this study was to understand the contribution of childhood maltreatment to GMC effects in individuals with cocaine use disorder.Methods: Individuals with cocaine use disorder were partitioned into groups of low vs. high childhood trauma based on median split of the total score of the Childhood Trauma Questionnaire (CTQ; CUD-L, N = 23; CUD-H, N = 24) and compared with age, race, and gender matched healthy controls with low trauma (N = 29). GMC was obtained using voxel-based morphometry applied to T1-weighted MRI scans. Drug use, depression and constraint were assessed with standardized instruments.Results: Whole-brain group comparisons showed reduced GMC in the right lateral orbitofrontal cortex (OFC) in CUD-H as compared with controls (cluster-level pFWE-corr < 0.001) and CUD-L (cluster-level pFWE-corr = 0.035); there were no significant differences between CUD-L and controls. A hierarchical regression analysis across both CUD groups revealed that childhood trauma, but not demographics and drug use, and beyond constraint and depression, accounted for 37.7% of the variance in the GMC in the right lateral OFC (p < 0.001).Conclusions: Beyond other contributing factors, childhood trauma predicted GMC reductions in the OFC in individuals with cocaine use disorder. These findings underscore a link between premorbid environmental stress and morphological integrity of a brain region central for behaviors underlying drug addiction. These results further highlight the importance of accounting for childhood trauma, potentially as a factor predisposing to addiction, when examining and interpreting neural alterations in cocaine addicted individuals. |
| first_indexed | 2024-12-12T14:09:11Z |
| format | Article |
| id | doaj.art-10ee46714329417cbec5322cafc5c53e |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-12T14:09:11Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-10ee46714329417cbec5322cafc5c53e2022-12-22T00:22:07ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-02-011210.3389/fnhum.2018.00051317669Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use DisorderKeren Bachi0Muhammad A. Parvaz1Scott J. Moeller2Scott J. Moeller3Gabriela Gan4Gabriela Gan5Anna Zilverstand6Rita Z. Goldstein7Nelly Alia-Klein8Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Psychiatry, Stony Brook University School of Medicine, Stony Brook, NY, United StatesDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesBackground: Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as documented separately in addiction and for childhood trauma. The purpose of this study was to understand the contribution of childhood maltreatment to GMC effects in individuals with cocaine use disorder.Methods: Individuals with cocaine use disorder were partitioned into groups of low vs. high childhood trauma based on median split of the total score of the Childhood Trauma Questionnaire (CTQ; CUD-L, N = 23; CUD-H, N = 24) and compared with age, race, and gender matched healthy controls with low trauma (N = 29). GMC was obtained using voxel-based morphometry applied to T1-weighted MRI scans. Drug use, depression and constraint were assessed with standardized instruments.Results: Whole-brain group comparisons showed reduced GMC in the right lateral orbitofrontal cortex (OFC) in CUD-H as compared with controls (cluster-level pFWE-corr < 0.001) and CUD-L (cluster-level pFWE-corr = 0.035); there were no significant differences between CUD-L and controls. A hierarchical regression analysis across both CUD groups revealed that childhood trauma, but not demographics and drug use, and beyond constraint and depression, accounted for 37.7% of the variance in the GMC in the right lateral OFC (p < 0.001).Conclusions: Beyond other contributing factors, childhood trauma predicted GMC reductions in the OFC in individuals with cocaine use disorder. These findings underscore a link between premorbid environmental stress and morphological integrity of a brain region central for behaviors underlying drug addiction. These results further highlight the importance of accounting for childhood trauma, potentially as a factor predisposing to addiction, when examining and interpreting neural alterations in cocaine addicted individuals.http://journal.frontiersin.org/article/10.3389/fnhum.2018.00051/fullcocaine dependencechildhood maltreatmentgray mattervoxel-based morphometryaddiction |
| spellingShingle | Keren Bachi Muhammad A. Parvaz Scott J. Moeller Scott J. Moeller Gabriela Gan Gabriela Gan Anna Zilverstand Rita Z. Goldstein Nelly Alia-Klein Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder Frontiers in Human Neuroscience cocaine dependence childhood maltreatment gray matter voxel-based morphometry addiction |
| title | Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder |
| title_full | Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder |
| title_fullStr | Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder |
| title_full_unstemmed | Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder |
| title_short | Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder |
| title_sort | reduced orbitofrontal gray matter concentration as a marker of premorbid childhood trauma in cocaine use disorder |
| topic | cocaine dependence childhood maltreatment gray matter voxel-based morphometry addiction |
| url | http://journal.frontiersin.org/article/10.3389/fnhum.2018.00051/full |
| work_keys_str_mv | AT kerenbachi reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT muhammadaparvaz reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT scottjmoeller reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT scottjmoeller reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT gabrielagan reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT gabrielagan reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT annazilverstand reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT ritazgoldstein reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder AT nellyaliaklein reducedorbitofrontalgraymatterconcentrationasamarkerofpremorbidchildhoodtraumaincocaineusedisorder |