Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder

Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder

Background: Childhood trauma affects neurodevelopment and promotes vulnerability to impaired constraint, depression, and addiction. Reduced gray matter concentration (GMC) in the mesocorticolimbic regions implicated in reward processing and cognitive control may be an underlying substrate, as docume...

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Bibliographic Details
Main Authors: Keren Bachi, Muhammad A. Parvaz, Scott J. Moeller, Gabriela Gan, Anna Zilverstand, Rita Z. Goldstein, Nelly Alia-Klein
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Human Neuroscience
Subjects:
cocaine dependence
childhood maltreatment
gray matter
voxel-based morphometry
addiction
Online Access:http://journal.frontiersin.org/article/10.3389/fnhum.2018.00051/full

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