The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort
Abstract Background and Aim The DanEoE is a previously described population‐ and register‐based cohort of 236 adult patients with eosinophilic esophagitis (EoE) in a well‐defined Danish region with a population of 580 000 and free medical treatment. The aim of the study was to compare the phenotype...
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| Format: | Article |
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Wiley
2023-08-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.12947 |
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| author | Stine D Henriksen Stine K Hansen Mia Heinesen Jacob H Terkelsen Martin Hollænder Kasper Bredal Dorte Melgaard Anne L Krarup |
| author_facet | Stine D Henriksen Stine K Hansen Mia Heinesen Jacob H Terkelsen Martin Hollænder Kasper Bredal Dorte Melgaard Anne L Krarup |
| author_sort | Stine D Henriksen |
| collection | DOAJ |
| description | Abstract Background and Aim The DanEoE is a previously described population‐ and register‐based cohort of 236 adult patients with eosinophilic esophagitis (EoE) in a well‐defined Danish region with a population of 580 000 and free medical treatment. The aim of the study was to compare the phenotype and treatment response between EoE patients with complications to patients without complications at diagnosis. Methods A retrospective cross‐sectional study of the DanEoE cohort's 236 adult EoE patients diagnosed between 2007 and 2017 in the North Denmark Region. Patients were divided into a group who had had complications (dilated or food bolus obstruction [FBO]) before or at the diagnosis, and a group without. Results At the diagnostic endoscopy, 61% had never had a complication, and 39% had either had FBO (n = 77) or been dilated (n = 15). The complicated group had the same mean age at symptom debut (37 [SD = 16] vs 37 [SD = 17] years, P = 1.0), but were diagnosed significantly later with a resulting longer diagnostic delay (13 [SD = 13] vs 7.9 [SD = 11] years, P = 0.01). Almost half of all patients were never treated to symptomatic remission (uncomplicated 40%, complicated 49%). The histological remission was not secured in the majority (uncomplicated 68%, complicated 70%). Despite this, <15% of patients with previous FBO experienced this after the diagnosis. Conclusion In the population‐based DanEoE cohort, results indicated that the complicated EoE phenotype was a patient with a 5‐year longer diagnostic delay. In the current study, the complication status did not predict the treatment response. |
| first_indexed | 2024-03-12T12:32:31Z |
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| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-03-12T12:32:31Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-10ee92d2641942abbd340834238c0b532023-08-29T07:34:25ZengWileyJGH Open2397-90702023-08-017855355810.1002/jgh3.12947The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohortStine D Henriksen0Stine K Hansen1Mia Heinesen2Jacob H Terkelsen3Martin Hollænder4Kasper Bredal5Dorte Melgaard6Anne L Krarup7Department of Gastrointestinal Surgery Aalborg University Hospital Aalborg DenmarkDepartment of Gastroenterology and Hepatology Aalborg University Hospital Aalborg DenmarkDepartment of Emergency Medicine and Trauma Center Aalborg University Hospital Aalborg DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkAbstract Background and Aim The DanEoE is a previously described population‐ and register‐based cohort of 236 adult patients with eosinophilic esophagitis (EoE) in a well‐defined Danish region with a population of 580 000 and free medical treatment. The aim of the study was to compare the phenotype and treatment response between EoE patients with complications to patients without complications at diagnosis. Methods A retrospective cross‐sectional study of the DanEoE cohort's 236 adult EoE patients diagnosed between 2007 and 2017 in the North Denmark Region. Patients were divided into a group who had had complications (dilated or food bolus obstruction [FBO]) before or at the diagnosis, and a group without. Results At the diagnostic endoscopy, 61% had never had a complication, and 39% had either had FBO (n = 77) or been dilated (n = 15). The complicated group had the same mean age at symptom debut (37 [SD = 16] vs 37 [SD = 17] years, P = 1.0), but were diagnosed significantly later with a resulting longer diagnostic delay (13 [SD = 13] vs 7.9 [SD = 11] years, P = 0.01). Almost half of all patients were never treated to symptomatic remission (uncomplicated 40%, complicated 49%). The histological remission was not secured in the majority (uncomplicated 68%, complicated 70%). Despite this, <15% of patients with previous FBO experienced this after the diagnosis. Conclusion In the population‐based DanEoE cohort, results indicated that the complicated EoE phenotype was a patient with a 5‐year longer diagnostic delay. In the current study, the complication status did not predict the treatment response.https://doi.org/10.1002/jgh3.12947eosinophilic esophagitiseosinophilic granulocytesfood bolus obstruction |
| spellingShingle | Stine D Henriksen Stine K Hansen Mia Heinesen Jacob H Terkelsen Martin Hollænder Kasper Bredal Dorte Melgaard Anne L Krarup The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort JGH Open eosinophilic esophagitis eosinophilic granulocytes food bolus obstruction |
| title | The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort |
| title_full | The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort |
| title_fullStr | The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort |
| title_full_unstemmed | The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort |
| title_short | The phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5‐year longer diagnostic delay: A population‐based study of the DanEoE cohort |
| title_sort | phenotype of adults with complicated eosinophilic esophagitis is dominated by a 5 year longer diagnostic delay a population based study of the daneoe cohort |
| topic | eosinophilic esophagitis eosinophilic granulocytes food bolus obstruction |
| url | https://doi.org/10.1002/jgh3.12947 |
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