Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases
The molecular pathology of diseases seen from the mitochondrial axis has become more complex with the progression of research. A variety of factors, including the failure of mitochondrial dynamics and quality control, have made it extremely difficult to narrow down drug discovery targets. We have id...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/11/3781 |
| _version_ | 1797566858970267648 |
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| author | Isshin Shiiba Keisuke Takeda Shun Nagashima Shigeru Yanagi |
| author_facet | Isshin Shiiba Keisuke Takeda Shun Nagashima Shigeru Yanagi |
| author_sort | Isshin Shiiba |
| collection | DOAJ |
| description | The molecular pathology of diseases seen from the mitochondrial axis has become more complex with the progression of research. A variety of factors, including the failure of mitochondrial dynamics and quality control, have made it extremely difficult to narrow down drug discovery targets. We have identified MITOL (mitochondrial ubiquitin ligase: also known as MARCH5) localized on the mitochondrial outer membrane and previously reported that it is an important regulator of mitochondrial dynamics and mitochondrial quality control. In this review, we describe the pathological aspects of MITOL revealed through functional analysis and its potential as a drug discovery target. |
| first_indexed | 2024-03-10T19:33:22Z |
| format | Article |
| id | doaj.art-10eeb5fba74d4b5382e335df6f453413 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:33:22Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-10eeb5fba74d4b5382e335df6f4534132023-11-20T01:53:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012111378110.3390/ijms21113781Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to DiseasesIsshin Shiiba0Keisuke Takeda1Shun Nagashima2Shigeru Yanagi3Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, JapanLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, JapanLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, JapanLaboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, JapanThe molecular pathology of diseases seen from the mitochondrial axis has become more complex with the progression of research. A variety of factors, including the failure of mitochondrial dynamics and quality control, have made it extremely difficult to narrow down drug discovery targets. We have identified MITOL (mitochondrial ubiquitin ligase: also known as MARCH5) localized on the mitochondrial outer membrane and previously reported that it is an important regulator of mitochondrial dynamics and mitochondrial quality control. In this review, we describe the pathological aspects of MITOL revealed through functional analysis and its potential as a drug discovery target.https://www.mdpi.com/1422-0067/21/11/3781mitochondriaE3 ubiquitin ligaseMITOL/MARCH5 |
| spellingShingle | Isshin Shiiba Keisuke Takeda Shun Nagashima Shigeru Yanagi Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases International Journal of Molecular Sciences mitochondria E3 ubiquitin ligase MITOL/MARCH5 |
| title | Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases |
| title_full | Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases |
| title_fullStr | Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases |
| title_full_unstemmed | Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases |
| title_short | Overview of Mitochondrial E3 Ubiquitin Ligase MITOL/MARCH5 from Molecular Mechanisms to Diseases |
| title_sort | overview of mitochondrial e3 ubiquitin ligase mitol march5 from molecular mechanisms to diseases |
| topic | mitochondria E3 ubiquitin ligase MITOL/MARCH5 |
| url | https://www.mdpi.com/1422-0067/21/11/3781 |
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