The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy
Chemokines interact with glycosaminoglycans of the extracellular matrix and activate heptahelical cellular receptors that mainly consist of G Protein-Coupled Receptors and a few atypical receptors also with decoy activity. They are well-described targets of oncogenic pathways and key players in canc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/3/848 |
| _version_ | 1797488624460103680 |
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| author | Géraldine Schlecht-Louf Claire Deback Françoise Bachelerie |
| author_facet | Géraldine Schlecht-Louf Claire Deback Françoise Bachelerie |
| author_sort | Géraldine Schlecht-Louf |
| collection | DOAJ |
| description | Chemokines interact with glycosaminoglycans of the extracellular matrix and activate heptahelical cellular receptors that mainly consist of G Protein-Coupled Receptors and a few atypical receptors also with decoy activity. They are well-described targets of oncogenic pathways and key players in cancer development, invasiveness, and metastasis acting both at the level of cancer cells and cells of the tumor microenvironment. Hence, they can regulate cancer cell proliferation and survival and promote immune or endothelial cell migration into the tumor microenvironment. Additionally, oncogenic viruses display the potential of jeopardizing the chemokine system by encoding mimics of chemokines and receptors as well as several products such as oncogenic proteins or microRNAs that deregulate their human host transcriptome. Conversely, the chemokine system participates in the host responses that control the virus life cycle, knowing that most oncoviruses establish asymptomatic latent infections. Therefore, the deregulated expression and function of chemokines and receptors as a consequence of acquired or inherited mutations could bias oncovirus infection toward pro-oncogenic pathways. We here review these different processes and discuss the anticancer therapeutic potential of targeting chemokine availability or receptor activation, from signaling to decoy-associated functions, in combination with immunotherapies. |
| first_indexed | 2024-03-10T00:04:56Z |
| format | Article |
| id | doaj.art-10f0f2c8391045acbca9b1800d922c28 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:04:56Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-10f0f2c8391045acbca9b1800d922c282023-11-23T16:09:38ZengMDPI AGCancers2072-66942022-02-0114384810.3390/cancers14030848The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer ImmunotherapyGéraldine Schlecht-Louf0Claire Deback1Françoise Bachelerie2Microbiome and Immunosurveillance, Université Paris-Saclay, INSERM, Inflammation, 92140 Paris, FranceMicrobiome and Immunosurveillance, Université Paris-Saclay, INSERM, Inflammation, 92140 Paris, FranceMicrobiome and Immunosurveillance, Université Paris-Saclay, INSERM, Inflammation, 92140 Paris, FranceChemokines interact with glycosaminoglycans of the extracellular matrix and activate heptahelical cellular receptors that mainly consist of G Protein-Coupled Receptors and a few atypical receptors also with decoy activity. They are well-described targets of oncogenic pathways and key players in cancer development, invasiveness, and metastasis acting both at the level of cancer cells and cells of the tumor microenvironment. Hence, they can regulate cancer cell proliferation and survival and promote immune or endothelial cell migration into the tumor microenvironment. Additionally, oncogenic viruses display the potential of jeopardizing the chemokine system by encoding mimics of chemokines and receptors as well as several products such as oncogenic proteins or microRNAs that deregulate their human host transcriptome. Conversely, the chemokine system participates in the host responses that control the virus life cycle, knowing that most oncoviruses establish asymptomatic latent infections. Therefore, the deregulated expression and function of chemokines and receptors as a consequence of acquired or inherited mutations could bias oncovirus infection toward pro-oncogenic pathways. We here review these different processes and discuss the anticancer therapeutic potential of targeting chemokine availability or receptor activation, from signaling to decoy-associated functions, in combination with immunotherapies.https://www.mdpi.com/2072-6694/14/3/848chemokineoncogenic virusesimmunotherapycancer |
| spellingShingle | Géraldine Schlecht-Louf Claire Deback Françoise Bachelerie The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy Cancers chemokine oncogenic viruses immunotherapy cancer |
| title | The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy |
| title_full | The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy |
| title_fullStr | The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy |
| title_full_unstemmed | The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy |
| title_short | The Chemokine System in Oncogenic Pathways Driven by Viruses: Perspectives for Cancer Immunotherapy |
| title_sort | chemokine system in oncogenic pathways driven by viruses perspectives for cancer immunotherapy |
| topic | chemokine oncogenic viruses immunotherapy cancer |
| url | https://www.mdpi.com/2072-6694/14/3/848 |
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