The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data
Objectives: Selenium deficiency can be associated with increased susceptibility to some viral infections and even more severe diseases. In this study, we aimed to examine whether this association applies to severe fever with thrombocytopenia syndrome (SFTS). Method: An observational study was conduc...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122200306X |
| _version_ | 1798032125170024448 |
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| author | Tian-Le Che Xin-Lou Li Jian-Bo Tian Gang Wang Xue-Fang Peng Hai-Yang Zhang Jia-Hao Chen Ying Zhu Wen-Hui Zhang Tao Wang Bao-Cheng Liu Qiang Xu Chen-Long Lv Bao-Gui Jiang Zhong-Jie Li Li-Qun Fang Wei Liu |
| author_facet | Tian-Le Che Xin-Lou Li Jian-Bo Tian Gang Wang Xue-Fang Peng Hai-Yang Zhang Jia-Hao Chen Ying Zhu Wen-Hui Zhang Tao Wang Bao-Cheng Liu Qiang Xu Chen-Long Lv Bao-Gui Jiang Zhong-Jie Li Li-Qun Fang Wei Liu |
| author_sort | Tian-Le Che |
| collection | DOAJ |
| description | Objectives: Selenium deficiency can be associated with increased susceptibility to some viral infections and even more severe diseases. In this study, we aimed to examine whether this association applies to severe fever with thrombocytopenia syndrome (SFTS). Method: An observational study was conducted based on the data of 13,305 human SFTS cases reported in mainland China from 2010 to 2020. The associations among incidence, case fatality rate of SFTS, and crop selenium concentration at the county level were explored. The selenium level in a cohort of patients with SFTS was tested, and its relationship with clinical outcomes was evaluated. Results: The association between selenium-deficient crops and the incidence rate of SFTS was confirmed by multivariate Poisson analysis, with an estimated incidence rate ratio (IRR, 95% confidence interval [CI]) of 4.549 (4.215−4.916) for moderate selenium-deficient counties and 16.002 (14.706−17.431) for severe selenium-deficient counties. In addition, a higher mortality rate was also observed in severe selenium-deficient counties with an IRR of 1.409 (95% CI: 1.061−1.909). A clinical study on 120 patients with SFTS showed an association between serum selenium deficiency and severe SFTS (odds ratio, OR: 2.94; 95% CI: 1.00–8.67) or fatal SFTS (OR: 7.55; 95% CI: 1.14–50.16). Conclusion: Selenium deficiency is associated with increased susceptibility to SFTS and poor clinical outcomes. |
| first_indexed | 2024-04-11T20:08:49Z |
| format | Article |
| id | doaj.art-10f1fb378d014eafbfee0b0b8907e002 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-11T20:08:49Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-10f1fb378d014eafbfee0b0b8907e0022022-12-22T04:05:14ZengElsevierInternational Journal of Infectious Diseases1201-97122022-09-011223845The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical dataTian-Le Che0Xin-Lou Li1Jian-Bo Tian2Gang Wang3Xue-Fang Peng4Hai-Yang Zhang5Jia-Hao Chen6Ying Zhu7Wen-Hui Zhang8Tao Wang9Bao-Cheng Liu10Qiang Xu11Chen-Long Lv12Bao-Gui Jiang13Zhong-Jie Li14Li-Qun Fang15Wei Liu16State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaDepartment of Medical Research, Key Laboratory of Environmental Sense Organ Stress and Health of the Ministry of Environmental Protection, PLA Strategic Support Force Medical Center, Beijing, P. R. ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, 430000, ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaCenter for Disease Control and Prevention of Central Theater Command, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, 430000, ChinaHealth Supervision Institute of Dongcheng District, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, P. R. China; Corresponding authors Prof Zhong-Jie Li, Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, 102206, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China; Corresponding authors Prof Wei Liu, and Prof Li-Qun Fang, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da Street, Fengtai District, Beijing 100071, P. R. ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, P. R. China; Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases, Beijing 100071, P. R. China; Graduate School of Anhui Medical University, Hefei 230601, P.R. China; Corresponding authors Prof Wei Liu, and Prof Li-Qun Fang, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da Street, Fengtai District, Beijing 100071, P. R. ChinaObjectives: Selenium deficiency can be associated with increased susceptibility to some viral infections and even more severe diseases. In this study, we aimed to examine whether this association applies to severe fever with thrombocytopenia syndrome (SFTS). Method: An observational study was conducted based on the data of 13,305 human SFTS cases reported in mainland China from 2010 to 2020. The associations among incidence, case fatality rate of SFTS, and crop selenium concentration at the county level were explored. The selenium level in a cohort of patients with SFTS was tested, and its relationship with clinical outcomes was evaluated. Results: The association between selenium-deficient crops and the incidence rate of SFTS was confirmed by multivariate Poisson analysis, with an estimated incidence rate ratio (IRR, 95% confidence interval [CI]) of 4.549 (4.215−4.916) for moderate selenium-deficient counties and 16.002 (14.706−17.431) for severe selenium-deficient counties. In addition, a higher mortality rate was also observed in severe selenium-deficient counties with an IRR of 1.409 (95% CI: 1.061−1.909). A clinical study on 120 patients with SFTS showed an association between serum selenium deficiency and severe SFTS (odds ratio, OR: 2.94; 95% CI: 1.00–8.67) or fatal SFTS (OR: 7.55; 95% CI: 1.14–50.16). Conclusion: Selenium deficiency is associated with increased susceptibility to SFTS and poor clinical outcomes.http://www.sciencedirect.com/science/article/pii/S120197122200306XSFTSSelenium deficiencyCFRClinic studySpatial study |
| spellingShingle | Tian-Le Che Xin-Lou Li Jian-Bo Tian Gang Wang Xue-Fang Peng Hai-Yang Zhang Jia-Hao Chen Ying Zhu Wen-Hui Zhang Tao Wang Bao-Cheng Liu Qiang Xu Chen-Long Lv Bao-Gui Jiang Zhong-Jie Li Li-Qun Fang Wei Liu The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data International Journal of Infectious Diseases SFTS Selenium deficiency CFR Clinic study Spatial study |
| title | The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data |
| title_full | The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data |
| title_fullStr | The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data |
| title_full_unstemmed | The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data |
| title_short | The role of selenium in severe fever with thrombocytopenia syndrome: an integrative analysis of surveillance data and clinical data |
| title_sort | role of selenium in severe fever with thrombocytopenia syndrome an integrative analysis of surveillance data and clinical data |
| topic | SFTS Selenium deficiency CFR Clinic study Spatial study |
| url | http://www.sciencedirect.com/science/article/pii/S120197122200306X |
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