Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil
Abstract INTRODUCTION: Brazil ranks first in the number of HTLV-1/-2-infected individuals worldwide. The high morbidity and mortality of HTLV-1-associated diseases, especially following infection in infancy, requires strong action to reduce vertical transmission. METHODS: To facilitate the apprais...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2021-03-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100632&tlng=en |
| _version_ | 1811245403440414720 |
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| author | Carolina Rosadas Adele Caterino-de-Araujo Graham Philip Taylor |
| author_facet | Carolina Rosadas Adele Caterino-de-Araujo Graham Philip Taylor |
| author_sort | Carolina Rosadas |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Brazil ranks first in the number of HTLV-1/-2-infected individuals worldwide. The high morbidity and mortality of HTLV-1-associated diseases, especially following infection in infancy, requires strong action to reduce vertical transmission. METHODS: To facilitate the appraisal of the implementation of the HTLV antenatal screening program by the Brazilian Ministry of Health, we determined the costs in distinct scenarios according to HTLV seroprevalence, specificity of the screening test, and type of confirmatory test. RESULTS: HTLV antenatal screening would cost R$ 55,777,012-R$ 77,082,123/year. Screening assays with high specificity reduce the need and cost of confirmatory assays by up to 25%. CONCLUSIONS: Careful selection of the screening assay is required to optimize the program. |
| first_indexed | 2024-04-12T14:39:33Z |
| format | Article |
| id | doaj.art-10f22d49619a4f1080d1b54948ed2d28 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T14:39:33Z |
| publishDate | 2021-03-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-10f22d49619a4f1080d1b54948ed2d282022-12-22T03:28:54ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492021-03-015410.1590/0037-8682-0853-2020Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in BrazilCarolina Rosadashttps://orcid.org/0000-0002-3922-5667Adele Caterino-de-AraujoGraham Philip TaylorAbstract INTRODUCTION: Brazil ranks first in the number of HTLV-1/-2-infected individuals worldwide. The high morbidity and mortality of HTLV-1-associated diseases, especially following infection in infancy, requires strong action to reduce vertical transmission. METHODS: To facilitate the appraisal of the implementation of the HTLV antenatal screening program by the Brazilian Ministry of Health, we determined the costs in distinct scenarios according to HTLV seroprevalence, specificity of the screening test, and type of confirmatory test. RESULTS: HTLV antenatal screening would cost R$ 55,777,012-R$ 77,082,123/year. Screening assays with high specificity reduce the need and cost of confirmatory assays by up to 25%. CONCLUSIONS: Careful selection of the screening assay is required to optimize the program.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100632&tlng=enHuman T cell lymphotropic virus (HTLV)DiagnosisScreening assaysSpecificityAntenatal care programCost-effectiveness |
| spellingShingle | Carolina Rosadas Adele Caterino-de-Araujo Graham Philip Taylor Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil Revista da Sociedade Brasileira de Medicina Tropical Human T cell lymphotropic virus (HTLV) Diagnosis Screening assays Specificity Antenatal care program Cost-effectiveness |
| title | Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil |
| title_full | Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil |
| title_fullStr | Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil |
| title_full_unstemmed | Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil |
| title_short | Specificity of HTLV screening tests and its impact on health care program costs: The perspective of antenatal screening in Brazil |
| title_sort | specificity of htlv screening tests and its impact on health care program costs the perspective of antenatal screening in brazil |
| topic | Human T cell lymphotropic virus (HTLV) Diagnosis Screening assays Specificity Antenatal care program Cost-effectiveness |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100632&tlng=en |
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