The avengers: SAMHD1 cooperates with MX2/MxB to defend against HIV-1

ABSTRACT SAMHD1 is an intrinsic limiting factor that effectively prevents HIV-1 infection in macrophages, dendritic cells, and resting CD4+ T cells. Extensive studies have underscored the indispensable role of the dNTPase activity of SAMHD1 in its antiviral function by primarily depleting dNTPs in q...

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Manylion Llyfryddiaeth
Prif Awduron: Zhi Wan, Gang Zhong, Huiqing Wang
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: American Society for Microbiology 2024-10-01
Cyfres:mBio
Pynciau:
Mynediad Ar-lein:https://journals.asm.org/doi/10.1128/mbio.01675-24