Dichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells

Dichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells

Abstract Background The requirement of the Mek1 inhibitor (iMek1) during naïve pluripotency maintenance results from the activation of the Mek1-Erk1/2 (Mek/Erk) signaling pathway upon leukemia inhibitory factor (LIF) stimulation. Methods Through a meta-analysis of previous genome-wide screening for...

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Bibliographic Details
Main Authors: Seong-Min Kim, Eun-Ji Kwon, Yun-Jeong Kim, Young-Hyun Go, Ji-Young Oh, Seokwoo Park, Jeong Tae Do, Keun-Tae Kim, Hyuk-Jin Cha
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Ptpn11
Shp2
Tyrosine phosphatase
Naïve pluripotency
Self-renewal
Mek1
Online Access:https://doi.org/10.1186/s13287-022-02976-z

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